Searchable abstracts of presentations at key conferences in endocrinology

ea0003p242 | Signalling | BES2002

Essential role of p38 mitogen-activated protein kinase in adipogenesis

Patel N , Holder J , Smith S , Kumar S , Eggo M

Human obesity is characterised by an increase in both the number of adipocytes and by an increase in their size, which is determined by adipogenesis. Adipogenesis can be induced in vitro in preadipocytes cultured in differentiation medium containing 3-isobutyl-1-methylxanthine, insulin, dexamethasone, and triiodothyronine but the signalling pathways important in adipogenesis are not well characterised. The p38 mitogen-activated protein kinase (MAPK) signalling pathway i...