Searchable abstracts of presentations at key conferences in endocrinology

ea0015s14 | System-specific effect steroids | SFEBES2008

Glucocorticoids, 11β HSDs and neuroprotection

Holmes Megan C

Glucocorticoids have profound effects on the brain, particularly during development and during the ageing process. The glucocorticoid metabolising enzymes, 11beta-hydroxysteroid dehydrogenases (11β-HSDs) type 1 and 2, interconvert active corticosterone (or cortisol) and inactive 11keto-derivatives to modify intracellular glucocorticoid levels. Hence, these enzymes add another layer of complexity to glucoocorticoid action in addition to circulating hormone and receptor (MR...

ea0031p141 | Growth and development | SFEBES2013

Impaired heart function and cardiac maturation in fetal mice with disrupted GR signalling in vascular smooth muscle and cardiomyocytes

Rog-Zielinska Eva A , Thompson Adrian , Moran Carmel , Kenyon Christopher J , Holmes Megan C , Chapman Karen E

Glucocorticoid signalling is essential for cardiac maturation late gestation. In mice, global glucocorticoid receptor deficiency (GR−/−) severely impairs cardiac function and ultrastructure at embryonic day (E) 17.5. To dissect direct effects of GR deficiency in the heart from effects on other systems, Sm22α-Cre mice were crossed with ‘floxed’ GR mice to generate SMGRKO mice with disrupted GR signalling in cardiomyocytes and vascular smoot...