Searchable abstracts of presentations at key conferences in endocrinology

ea0065p4 | Adrenal and Cardiovascular | SFEBES2019

Serum estrogens and the sexual dimorphism in heritable and idiopathic pulmonary arterial hypertension (PAH)

Denver Nina , Homer Natalie ZM , Austin Eric D , Andrew Ruth , MacLean Margaret R

Serum was collected with ethical approval from Vanderbilt Medical Center, USA for blinded analysis between clinical phenotypes; heritable and idiopathic PAH patients (hPAH n=13, 14; iPAH n=7, 12) compared to non-PAH control (n =17, 17) (female, males, respectively). Quantification of circulating estrogens in human bio-fluids may reveal insights into disease aetiology but has been hampered through inadequate sensitivity and specificity of immunoassays...

ea0065p231 | Metabolism and Obesity | SFEBES2019

Mammary adipose tissue steroid activation and its relevance for breast cancer prognosis

Laforest Sofia , Denver Nina , Homer Natalie ZM , Durocher Francine , Walker Brian R , Andrew Ruth , Tchernof Andre

Background: Adipose tissue dysfunction could partially explain the well-demonstrated association between obesity and survival in breast cancer (BC). Oestrogen and glucocorticoid concentrations and their respective activation enzymes, oestrogenic 17β-hydroxysteroid dehydrogenases (17βHSDs) and aromatase, and 11βHSD1 are increased in adipocyte hyperplasia and hypertrophy, supporting the hypothesis of a potential role for locally generated steroids in obesity-assoc...

ea0073oc15.1 | Oral Communications 15: Late Breaking | ECE2021

Differential steroidomic profiles of human visceral and subcutaneous adipose tissue before and after bariatric surgery-induced weight loss

Laforest Sofia , Denham Scott , Denver Nina , Biertho Laurent , Homer Natalie Z.M. , Andrew Ruth , Tchernof Andre

BackgroundObesity is closely associated with impaired adipose tissue function. Although bariatric surgery is the treatment of choice for severe obesity and its related conditions, there are conflicting data on the reversal of adipose tissue dysfunction after surgery-induced weight loss. We hypothesise that local steroid hormone availability influences fat deposition or mobilisation and that these changes track with weight loss improvements, because plasm...

ea0086oc4.3 | Adrenal and Cardiovascular | SFEBES2022

Plasma steroid concentrations reflect disease severity during acute illness but not recovery after hospitalisation with COVID-19

Devine Kerri , Walker Brian R , Homer Natalie ZM , Openshaw Peter JM , Kenneth Baillie J. , Andrew Ruth , Wain Louise V , Semple Malcolm G , Reynolds Rebecca M

Background: Endocrine systems are known to be disrupted in acute illness, and we previously demonstrated that plasma steroid concentrations correlated with severity in patients hospitalised with COVID-19. Given their similarity to some clinical hormone deficiencies, we hypothesised that ‘long-COVID’ symptoms may be related to ongoing endocrine dysfunction.Methods: Plasma steroids, precursors and metabolites were quantified by LCMS/MS in multi-c...

ea0056gp58 | Bone and Osteoporosis | ECE2018

Investigating glucocorticoids as mediators of increased bone marrow adiposity during caloric restriction

Lovdel Andrea , Suchacki Karla , Sulston Richard J , Wallace Robert J , Macpherson Gavin , Stimson Roland H , Homer Natalie ZM , Chapman Karen E , Cawthorn William P

Background: Bone marrow adipose tissue (BMAT) comprises >10% of total adipose mass in healthy humans and further increases in diverse clinical conditions, including obesity/diabetes, osteoporosis and following caloric restriction (CR). However, why BMAT increases during CR remains unknown. One possibility is that this is mediated by glucocorticoid (GC) excess. GC action on target tissues depends on circulating and intracellular concentrations of t...

ea0077p1 | Adrenal and Cardiovascular | SFEBES2021

Plasma steroid profiles in patients hospitalised with COVID-19 - an ISARIC/WHO CCP-UK cohort study

Devine Kerri , Russell Clark D , Moore Shona C , Thwaites Ryan S , Hardwick Hayley E , Oosthuyzen Wilna , Dunning Jake , Turtle Lance , Blanco Giovanny Rodriguez , Kriegsheim Alex von , Walker Brian R , Homer Natalie ZM , Openshaw Peter JM , Baillie J Kenneth , Semple Malcolm G , Andrew Ruth , Reynolds Rebecca M

Background: Secretion and metabolism of glucocorticoids and sex steroids is disrupted in critical illness, and may be further disrupted in COVID-19. The host receptor (ACE-2) is expressed in endocrine tissues including adrenal cortex and gonad, and its occupancy may dysregulate the renin-angiotensin system. We hypothesise that severe COVID-19 results in glucocorticoid and sex hormone deficiency, and aldosterone excess.Methods: Plasma was obtained from 27...