Searchable abstracts of presentations at key conferences in endocrinology

ea0021p159 | Diabetes and metabolism | SFEBES2009

Brain natriuretic peptide shows no response to acute hypobaric hypoxia in humans

Woods David , Hooper Tim , Mellor Adrian , Hodkinson Pete , Wakeford Rob , Peaston Bob , Ball Steve , Green Nic

Background: Effective acclimatization to high altitude involves a natriuresis and diuresis facilitated by a suppressed aldosterone. Acute mountain sickness (AMS) is common but poorly understood. A cardiac hormone, brain natriuretic peptide (BNP), is released primarily in response to cardiomyocyte stretch but animal models suggest BNP secretion is also stimulated by acute hypoxia. An increase in BNP causes a diuresis, natriuresis and a reduction in aldosterone. We hypothesized ...

ea0028p216 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2012

Severe Acute Mountain Sickness and Brain Natriuretic Peptide in Humans

Stacey Mike , Mellor Adrian , Boos Christopher , Smith Chris , Hooper Tim , Jo Yarker , Hodkinson Pete , Green Nic , Woods David

We have previously reported that exercise at high altitude (HA) led to a significant increase in brain natriuretic peptide (BNP) levels. In contrast two other publications have reported no change in resting BNP at HA. We therefore measured BNP and Lake Louise (LL) Acute Mountain Sickness (AMS) scores in a further 20 subjects at rest in Kathmandu (Kat; 1300 m); and following exercise and at rest at 4270 m and 5150 m. Compared with the baseline BNP level at Kat (9.2+/−2 pg...

ea0028p318 | Steroids | SFEBES2012

The cortisol response to hypobaric hypoxia at rest and post-exercise

Stacey Mike , Davison Andrew , Mellor Adrian , Smith Chris , Hooper Tim , Neely Dermot , Peaston Bob , Turner Steve , Woods David

High altitude exposure leads to a marked natriuresis and diuresis facilitated by a reduced resting and subdued post-exercise aldosterone. There is a strong correlation between aldosterone and cortisol at high altitude and although most, but not all, investigators report a rise in cortisol with ascent very little data exist regarding the post-exercise response in cortisol. We therefore measured salivary cortisol in a cohort of 45 subjects post-exercise and 20 subjects at rest w...

ea0025p144 | Diabetes, metabolism and cardiovascular | SFEBES2011

Brain natriuretic peptide rises with exercise at high altitude and is associated with acute mountain sickness scores

Woods David , Hooper Tim , Hodkinson Pete , Ball Steve , Wakeford Rob , Peaston Bob , Bairsto Claire , Green Nic , Mellor Adrian

Acute mountain sickness (AMS) is common at high altitude (HA) and is associated with a relative failure of the natriuresis and diuresis that occurs at HA. The role of brain natriuretic peptide (BNP) in this context has not been thoroughly investigated. We aimed to clarify if BNP rises in response to exercise at HA and if so whether this is related to markers of acclimatization. Thirty-two healthy subjects had assessments of BNP, aldosterone and markers of HA acclimatization (a...