Searchable abstracts of presentations at key conferences in endocrinology

ea0022p672 | Obesity | ECE2010

Testosterone gel significantly increase lean body mass in ageing males with relatively low bio-available testosterone and waist circumference above 94 cm: a double blinded, randomized, placebo controlled 6 months study

Frederiksen Louise , Hougaard David M , Brixen Kim , Andersen Marianne

Background: Testosterone replacement therapy in severe hypogonadism is indicated, however, the treatment of late onset hypogonadism (LOH) is debated, especially what the diagnostic criteria should be. In LOH bio-available testosterone probably gives a more accurate index of gonadal status as a diagnostic criterion as it takes SHBG into consideration. SHBG is known to increase with ageing, however, SHBG is also negatively influenced by insulin and visceral adiposity.<p clas...

ea0037gp.13.06 | Diabetes and obesity – Translational cardiovascular and obesity | ECE2015

Effects of testosterone replacement therapy on lean body mass, total fat mass, and insulin sensitivity in aging men with type 2 diabetes - a randomised, double-blinded, placebo-controlled trial

Magnussen Line Velling , Glintborg Dorte , Hermann Pernille , Hougaard David M , Hojlund Kurt , Andersen Marianne S

Lowered testosterone levels may be observed in up to 50% of ageing men with type 2 diabetes (T2D). Testosterone replacement therapy (TRT) increases lean body mass in men with lowered testosterone levels and T2D, but the effect of TRT on glucose metabolism has not been evaluated by euglycemic hyperinsulinemic clamp.We used gold standard methods to evaluate the effect of TRT on body composition, insulin sensitivity, and oxidative metabolism in men with T2D...