ea0042p2 | (1) | Androgens2016
Helsen Christine
, Prekovic Stefan
, van Royen Martin E
, Houtsmuller Adriaan B
, Fuentes-Prior Pablo
, Estebanez-Perpina Eva
, Claessens Frank
The androgen receptor (AR) is a multidomain transcription factor consisting of an aminoterminal domain (NTD), a DNA binding domain (DBD) and a ligand binding domain (LBD). Binding of androgens marks the start of a sequence of intra- and interdomain communications, DNA binding, coregulator recruitment and gene activation. Besides the DBD-mediated dimerization on the DNA, there is a functionally relevant N/C interaction. The contribution of the intra- and intermolecular N/C inte...