Endocrine Abstracts

A 55-year-old lady presented with visual deterioration of 2 years duration affecting both eyes. Initial examination demonstrated reduced visual acuity in the LE at finger perception and RE 6/9 with right temporal superior quadrantopia. Rest of the systemic examination was unremarkable. Relevant endocrine tests revealed a FSH-146.9 U/l and FT4-14 pmol/l. MRI pituitary demonstrated a pituitary adenoma with significant suprasellar component compressing the optic nerves...

Turner’s syndrome is one of the most common chromosomal abnormalities affecting 1 in 2500 live births. Short stature and gonadal dysgenesis are known as the hallmarks of the syndrome since Henry Turner described the original cases in the late 1930s. Although the majority of these patients have streak ovaries as a result of stromal fibrosis, the uterus is intact, albeit with atrophic endometrium due to the hypoestrogenic state. We report a case of ...

A 55-year-old lady was admitted with sudden onset headache, diplopia, photophobia and confusion. CT brain showed SAH with hydrocephalus. Coiling of the aneurysm with EVD insertion was done on the same day. On day 5 post-operatively she developed hyponatremia and dropped her GCS to 10/15.On examination she was volume depleted with dry mucous membranes and loss of skin turgor. Urine output over the previous 4 days had been 2.5–4 l/day, urinary sodium ...

Pituitary metastases are uncommon, with breast and lung carcinomas being the most common primary sites. Of the minority that are symptomatic, diabetes insipidus (DI) is frequently present. We report two cases, one presenting with DI and the other with hypopituitarism and DI, who deteriorated rapidly and died within 3 months.Case 1: A previously fit 53-year-old lady presented in December 2008 with a one month history of polyuria and polydipsia. Investigat...

A 62-year-old man presented with 1 month history of lethargy, nocturia, thirst and diplopia. On examination he had left 3rd nerve palsy with complete ptosis. MRI pituitary demonstrated a 1.3×1.1 cm enhancing mass on the left side of the pituitary gland, with invasion of the left cavernous sinus. Endocrine work up revealed partial DI, TSH and gonadotrophin deficiency. Because of unusual appearance of the pituitary lesions, a biopsy was arranged but initial histology was in...

Primary aldosteronism (PA) uncommonly presents during pregnancy. Uncontrolled blood pressure may result in adverse maternal and fetal outcomes. We report a case presenting in pregnancy whose management proved particularly challenging, due to variable compliance with therapy, frequent non-attendance at clinic, a subsequent pregnancy and negative imaging.A 24 year old woman presented at 26 weeks gestation with severe pre-eclampsi...

Primary aldosteronism (PA) uncommonly presents during pregnancy. Uncontrolled blood pressure may result in adverse maternal and fetal outcomes. We report a case presenting in pregnancy whose management proved particularly challenging, due to variable compliance with therapy, frequent non-attendance at clinic, a subsequent pregnancy and negative imaging.A 24 year old woman presented at 26 weeks gestation with severe pre-eclampsi...

Introduction: Immobilization hypercalcemia (IH) is more common in children and adolescent due to increased rate of bone turnover and it usually develop 4–6 weeks post trauma but it can begin as early as 2 weeks and as late as six months. We report a patient who developed severer hypercalcemia after sustaining multiple fractures and immobilization.CaseA 24-year-old man was admitted for neurorehabilitation after road traffic acc...

Case: A 77-year-old man was admitted with a pathological fracture of the right femur, which required intramedullary nailing. He had previously been diagnosed with Paget’s disease affecting the right femur and also hyperparathyroidism with a large parathyroid adenoma on Sestamibi scan which had been managed at another hospital. On this admission, his corrected calcium was 2.79 (2.15–2.55) mmol/l, PTH 643 (15–65) pg/ml and alkaline phosphatase 258 (30–130) U/...

Hypomagnesaemia usually occurs secondary to decreased intestinal absorption or excessive renal excretion. There have been a few reports recently suggesting an association between PPIs and hypomagnesaemia.A 65-year-old lady was referred to the endocrine clinic for investigation of hypomagnesaemia found on routine testing. Serum magnesium was 0.27 mmol/l (normal 0.7–1.0), with corrected serum calcium of 2.0 mmol/l (2.12–2.63), and normal PTH and ...