Searchable abstracts of presentations at key conferences in endocrinology

ea0020htb1 | Hot topics: Basic | ECE2009

Hot topics: Basic

Spyroglou Ariadni , Wagner Sibylle , Manolopoulou Jenny , Hantel Constanze , Reincke Martin , Bidlingmaier Martin , Hrabe de Angelis Martin , Beuschlein Felix

Although primary aldosteronism (PA) is considered to be the most prevalent cause of secondary hypertension the underlying genetic mechanisms have been elucidated only for the rare familial forms of the disease. In an attempt to define novel genetic loci involved in the pathophysiology of PA a phenotype-driven mutagenesis screening after treatment with the alkylating agent N-ethyl-N-nitrosourea was established for the parameter aldosterone. The aldosterone values ...