Searchable abstracts of presentations at key conferences in endocrinology

ea0032p661 | Male reproduction | ECE2013

Changes of neuroactive steroids caused by the smoking discontinuance

Duskova Michaela , Hruskovicova Hana , Hill Martin , Pospisilova Hana , Kralikova Eva , Starka Luboslav

Introduction: Tobacco dependence is considered to be a serious psycho-social problem. Chronic smoking can cause fertility disorders with both sexes. The literature brings up contradictory results in relation to the effects of the smoking on the steroid hormones levels. Only a few papers discuss the effect of the nicotine addiction treatment.Methods: We observed 26 smokers who decided to quit smoking and abstained from smoking for one year. With everyone ...

ea0032p975 | Steroid metabolism and action | ECE2013

Impact of smoking on neuroactive steroids

Hruskovicova Hana , Duskova Michaela , Hill Martin , Vondra Karel , Kralikova Eva , Starka Luboslav

Introduction: The dependence on tobacco, diagnosis F 17, is an independent condition in the International classification of diseases and presents one of the most widespread addictions. Chronic smoking can cause impairment of fertility in both sexes. However, only a small number of studies were dedicated to the influence of smoking on levels of steroid hormones and their neuroactive metabolites. Neuroactive steroids modulate the effects of tobacco on central nervous system, and...

ea0026p126 | Female reproduction | ECE2011

Cigarette smoking and progesterone and androgen metabolites in premenopausal women

Duskova Michaela , Simunkova Katerina , Hill Martin , Hruskovicova Hana , Pospisilova Hana , Kralikova Eva , Starka Luboslav

Objective: Chronic smoking alters the circulating levels of sex hormones and possibly also the neuroactive steroids, however, the data available is limited.Patients and methods: Therefore, a broad spectrum of free and conjugated steroids and related substances was quantified by GC–MS and RIA in premenopausal smokers and in age-matched (38.9±7.3 years of age) non-smokers in the follicular (FP) and luteal phases (LP) of menstrual cycle (10 non-sm...

ea0026p127 | Female reproduction | ECE2011

Influence of smoking cessation on steroid spectrum in premenopausal women

Pospisilova Hana , Duskova Michaela , Simunkova Katerina , Hruskovicova Hana , Hill Martin , Kralikova Eva , Starka Luboslav

Background: Smoking represents the most widespread substance dependence in the world. Several studies show the nicotine’s ability to alter women hormonal homeostasis. Women smokers have higher testosterone and lower estradiol levels throughout life compared to women non-smokers. This negatively affects women reproductive function. Furthermore, alteration of neuroactive and neuroprotective steroids occurs in women smokers, which plays an important role in the activity of t...

ea0026p352 | Steroid metabolism | ECE2011

Effect of smoking cessation on steroid balance in postmenopausal women

Hruskovicova Hana , Duskova Michaela , Simunkova Katerina , Hill Martin , Pospisilova Hana , Kralikova Eva , Vondra Karel , Starka Luboslav

Introduction: Cigarette smoking is one of the most serious substance abuse problems. It is generally accepted that nicotine and other chemicals in tobacco smoke alter endocrine function in women, induce changes in female hormonal balance and likely contributes to reported associations of smoking with adverse reproductive outcomes, including menstrual dysfunction, infertility, and earlier menopause. Studies on the effects of smoking and smoking cessation on female sex hormones ...

ea0022p206 | Clinical case reports and clinical practice | ECE2010

The role of salivary α-amylase in prediction of failure of smoking cessation

Duskova Michaela , Simunkova Katerina , Hill Martin , Hruskovicova Hana , Hoskovcova Petra , Kralikova Eva , Starka Luboslav

Background: A high percentage of adult smokers try to quit, but most of these attempts fail. The ability to predict the success or failure of smoking cessation efforts will be useful for clinical practice. Stress response is regulated by two primary neuroendocrine systems. Salivary cortisol has been used as a marker for the hypothalamus-pituitary-adrenocortical axis and salivary α-amylase as a marker for the sympathetic adrenomedullary system.Method...

ea0022p743 | Steroid metabolism & action | ECE2010

Levels of 7-hydroxy DHEA derivates during menstrual cycle

Hruskovicova Hana , Duskova Michaela , Simunkova Katerina , Hill Martin , Vondra Karel , Starka Luboslav

Introduction: 7-hydroxyl DHEA derivatives are labelled as natural anti-glucocorticoid and neuroprotective substances. Their impact on the production of cytokines, their activation of apoptosis, influence on the migration of macrophages to peripheral tissue, their possible effect on angiogenesis, effect on inflammatory mediators (arachidonic acid metabolites) and their role in the mechanism of oxidative stress have been described.Methods: In our study we ...

ea0022p63 | Adrenal | ECE2010

Adrenal non-producing adenomas show indirect signs of glucocorticoid excess and hypercortisolism correlates with differential blood counts

Sagert Cornelia , Hruskovicova Hana , Haase Matthias , Mansmann Georg , Schinner Sven , Schott Matthias , Scherbaum Werner A , Willenberg Holger S

Despite their nature of being clinically inapparent, subtle laboratory abnormalities are sometimes detected in patients with adrenal incidentalomas and the question arises whether these changes justify surgical intervention in a patient with an otherwise benign adrenal tumour. Therefore, we aimed at finding further expressions of adrenal hormone excess that reflect net glucocorticoid action.Since glucocorticoids are potent immune suppressants we studied ...