Searchable abstracts of presentations at key conferences in endocrinology

ea0011p293 | Diabetes, metabolism and cardiovascular | ECE2006

Glucocorticoids are metabolised within perivascular adipose: the link between metabolic diseases and their vascular consequences?

Dover AR , Huang CJ , Livingstone DE , Raubenheimer PJ , Hadoke PWF , Walker BR , Reynolds RM

The metabolism of glucocorticoids within adipose tissue, by the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11HSD1), is known to be altered in obesity and following high fat feeding. Until recently, little attention has been paid to the fat depots found directly adjacent to blood vessels. Emerging evidence suggests that perivascular adipose may play a key role in modulating vascular function. The presence of steroidogenic enzymes within perivascular adipose, and the eff...