ea0016oc2.1 | Thyroid | ECE2008
Hubner Caroline
, Weber Martin
, Biebermann Heike
, Herrmann Bernhard
, Gruters Annette
, Krude Heiko
Background: Defective thyroid gland development occurs in 80% of congenital hypothyroidism (incidence of 1:30001:4000). Only <5% have been shown to be caused by molecular genetic defects in few transcription factor genes (Nkx2.1, Nkx2.5, Foxe1, Pax8, Hhex) which are known to play a role in thyroid gland development. Therefore, other genes with a critical role in early thyroid development are likely to be involved in the pathogenesis of thyroid dysgenesis.<p class...