Endocrine Abstracts

Thyroxine is crucial for normal human brain development in utero and for the first two years after birth. Brain damage through deficiency of T4 is irreversible and the degree and spectrum of subsequent neurodevelopmental disorders is dependent on the timing and severity of T4 deprivation; this presentation will review the current clinical evidence.Maternal to fetal transfer of thyroxine is essential for the first half of gestation, and to a lesser, and d...