Endocrine Abstracts

Cyclical Cushing’s syndrome is typically detected by collecting sequential daily early morning urine (EMU) samples for cortisol to creatinine ratio over a 28 day period. More recently nocturnal salivary cortisol (NSC) measurement has been shown to be a sensitive means of screening for Cushing’s syndrome. The Endocrine Society have suggested that NSC may be used to assess patients for cyclical Cushing’s however there is limited evidence that it correlates with th...

Aberrant and upregulated eutopic receptors have been identified in vitro in patients with primary aldosteronism (PA). We previously identified an exaggerated aldosterone response to synacthen in patients with PA versus healthy controls. In this study we aimed to evaluate whether the synacthen test differentiates between patients with PA and essential hypertension (EH). The 250 mcg intramuscular synacthen test was performed after 30 minutes recumbency in the morning and off int...

Background: Pituitary neuroendocrine tumours (PitNETs) have almost invariably benign histopathological characteristics but result in comorbidity and mortality. There has been interest in the composition of the PitNET immune microenvironment, particularly with the advent of immunotherapy-associated hypophysitis linked to PD-L1 and CTLA-4 checkpoint inhibitors. The innate immune cGAS-STING pathway is activated by DNA damage and DNA damage is a known feature of somatotrophinomas....