Searchable abstracts of presentations at key conferences in endocrinology

ea0028p319 | Steroids | SFEBES2012

The use of nocturnal salivary cortisol and urinary cortisol to creatinine ratio in the evaluation of cycling in patients with Cushing’s syndrome

Graham Una , Hunter Stephen , McDonnell Margaret , Mullan Karen , Atkinson Brew

Cyclical Cushing’s syndrome is typically detected by collecting sequential daily early morning urine (EMU) samples for cortisol to creatinine ratio over a 28 day period. More recently nocturnal salivary cortisol (NSC) measurement has been shown to be a sensitive means of screening for Cushing’s syndrome. The Endocrine Society have suggested that NSC may be used to assess patients for cyclical Cushing’s however there is limited evidence that it correlates with th...

ea0028p320 | Steroids | SFEBES2012

Use of the 250mcg short synacthen test to differentiate between patients with primary aldosteronism and essential hypertension

Graham Una , Hunter Stephen , McCance David , Atkinson Brew , Mullan Karen

Aberrant and upregulated eutopic receptors have been identified in vitro in patients with primary aldosteronism (PA). We previously identified an exaggerated aldosterone response to synacthen in patients with PA versus healthy controls. In this study we aimed to evaluate whether the synacthen test differentiates between patients with PA and essential hypertension (EH). The 250 mcg intramuscular synacthen test was performed after 30 minutes recumbency in the morning and off int...