Searchable abstracts of presentations at key conferences in endocrinology

ea0044p10 | Adrenal and Steroids | SFEBES2016

11β-Hydroxysteroid Dehydrogenase Type 1 within Muscle Protects Against the Adverse Effects of Local Inflammation and Muscle Wasting

Hardy Rowan , Hussain Zahrah , Filer Andrew , Buckley Christopher , Lavery Gareth , Cooper Mark , Raza Karim

Muscle wasting is a common feature of inflammatory myopathies. Glucocorticoids (GCs), whilst effective at suppressing inflammation and inflammatory muscle loss, also cause myopathy with prolonged administration. 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) is a bidirectional GC activating enzyme, potently up-regulated by inflammation within mesenchymal derived tissues. We assessed the regulation of this enzyme with inflammation in muscle and examined its functi...