Searchable abstracts of presentations at key conferences in endocrinology

ea0029p752 | Endocrine Disruptors | ICEECE2012

Treatment with resveratrol resulted in an inhibition of cell proliferation induced by 17 β-estradiol or various endocrine disrupting chemicals via down-regulating the cell cycle progression in BG-1 ovarian cancer cells

Kang N. , Hwang K. , Choi K.

Resveratrol (trans-3,4,5-trihydroxystilbene, RES), a phytoestrogen, exists in grape skin and red wine. Endocrine disrupting chemicals (EDCs) appear to promote the development and progression of the estrogen dependant cancers. In this study, we evaluated the inhibitory effect of RES on the cell growth and progression induced by various EDCs in BG-1 ovarian cancer cells expressing estrogen receptors (ERs). The various EDCs, i.e., bisphenol A (BPA), nonylphenol (NP), octylphenol ...

ea0029p756 | Endocrine Disruptors | ICEECE2012

A phytoestrogen, genistein, reversed 17 β-estradiol or bisphenol A-induced cell growth via downregulation of the cell cycle progression in BG-1 ovarian cancer cells

Hwang K. , Kang N. , Choi K.

One of estrogens, 17b-estradiol (E2), is a pleiotropic hormone that regulates the growth and differentiation of many tissues and also acts as a mitogen that promotes the development and proliferation of hormone-responsive cancers. Bisphenol A (BPA) is a widely used industrial compound and classified as one of endocrine disrupting chemicals (EDCs) and especially a xenoestrogen that imitates estrogen in living organisms. In this study, we examined the effect of a phytoestrogen, ...

ea0029p946 | Female Reproduction | ICEECE2012

Inhibin-α gene promoter polymorphisms in patients with idiopathic premature ovarian failure

Yoon S. , Kim J. , Chae S. , Hwang K. , Choi Y\.

Background: Premature ovarian failure (POF) is a complex disorder defined as the cessation of ovarian function before or at the age of 40. Although the etiology of POF remains unknown in a large proportion of cases, it has been suggested that variations in the Inhibin α gene (INHA) may affect the ovarian function of women. This study was performed to investigate whether the genetic polymorphisms of the INHA gene are associated with idiopathic POF in a Korean population.</...

ea0029p908 | Female Reproduction | ICEECE2012

Prevalence of elevated glycated hemoglobin in women with polycystic ovary syndrome: according to the recently defined criteria

Chae S. , Kim J. , Choi Y. , Hwang K. , Yoon S. , Kim K.

Background: Insulin resistance is a core pathophysiology of polycystic ovary syndrome (PCOS). The screening recommendations for type 2 diabetes in PCOS patients have varied according to organizations, but the AE-PCOS Society recommended that a OGTT be performed in obese patients or in lean patients with advanced age (>40 year), with a history of gestational diabetes, or with a family history of type 2 diabetes. Recently, the American Diabetes Association (ADA) newly includ...

ea0029p909 | Female Reproduction | ICEECE2012

Most of type 2 diabetes associated loci identified in genome-wide association studies are not associated with polycystic ovary syndrome

Yoon S. , Kim J. , Choi Y. , Hwang K. , Chae S. , Kim K.

Objective: Insulin resistance is a core feature of polycystic ovary syndrome (PCOS), thus, it may be the common link between PCOS and type 2 diabetes (T2DM).Although the etiology of PCOS has not been elucidated, a number of studies have suggested that genetic factors may play important roles in its etiology and pathogenesis. If PCOS and T2DM share a common genetic background, genetic variants determining the risk of T2DM may also be associated with PCOS....