Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

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ea0032p1002 | Thyroid (non-cancer) | ECE2013

Diagnosis of hypothyroidism is associated to an increased risk of acute decompensated heart failure occurrence, but not of mortality among heart failure outpatients

Triggiani Vincenzo , Iacoviello Massimo , Puzzovivo Agata , Antoncecchi Valeria , Angelo Giagulli Vito , Guastamacchia Edoardo , Favale Stefano

It has been demonstrated that hypothryoidism could affect the prognosis of patients with cardiovascular disease. The aim of this study was to better clarify the prognostic role of hypothyroidism in patients with chronic heart failure (CHF).We enrolled 384 consecutive outpatients (65±13 years, 296 males, NYHA 2.3±0.6, left ventricular ejection fraction, LVEF, 32±9%) with CHF (ESC criteria), in stable clinical conditions (at least 30 days) a...
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ea0022p751 | Thyroid | ECE2010

Role of hypothyroidism in predicting a worse prognosis of heart failure outpatients treated with amiodarone

Triggiani Vincenzo , Iacoviello Massimo , Guastamacchia Edoardo , Guida Pietro , Forleo Cinzia , Puzzovivo Agata , Tafaro Emilio , Favale Stefano

Amiodarone, an iodine-containing antiarrhythmic drug frequently used in chronic heart failure (CHF) patients, is often the cause of primary hypothyroidism. It has not been well investigated, however, whether its use could lead to a poor prognosis in these patients by inducing and/or worsening thyroid function. The aim of this study was to evaluate the prognostic significance of hypothyroidism detection in CHF outpatients treated with amiodarone. Out of 355 patients affected by...
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ea0020p124 | Thyroid | ECE2009

Prognostic role of sub-clinical hypothyroidism in chronic heart failure outpatients

Guastamacchia Edoardo , Triggiani Vincenzo , Iacoviello Massimo , Guida Pietro , Forleo Cinzia , Catanzaro Raffaella , Tafaro Emilio , Favale Stefano

The aim of this study was to evaluate the prognostic role of subclinical hypothyroidism in patients with chronic heart failure (CHF). We evaluated 338 consecutive outpatients (260 male; age 64±13) with stable CHF (NYHA class 2.3±0.6) receiving conventional therapy (ACE inhibitors and/or ARBs 93%, Beta-blockers 88%, Digitalis 26%, Diuretics 85%, Spironolactone 54%, Amiodarone 32%). The patients underwent a physical examination, electrocardiography and echocardiography...
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ea0037ep629 | Obesity and cardiovascular endocrinology | ECE2015

IGF-1 levels correlate with T3 status in chronic heart failure outpatients: preliminary data

Triggiani Vincenzo , Iacoviello Massimo , Leone Marta , Giagulli Vito Angelo , Guastamacchia Edoardo , Salzano Andrea , Bobbio Emanuele , Arcopinto Michele , Cittadini Antonio

Background: A variety of hormones may be down-regulated in CHF patients. Impaired activity of the GH/IGF-1 axis has been described and is associated with poor clinical status and outcome. Moreover, a decrease in serum T3 is correlated to the severity of the heart disease as assessed by the NYHA classification. Aim of this study was to evaluate a possible correlation between IGF-1 levels and T3 status in a cohort of CHF outpatients.M...
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ea0049gp214 | Thyroid 2 | ECE2017

Thyroid hormones deficiencies and poor outcome in chronic heart failure outpatients

Triggiani Vincenzo , Licchelli Brunella , Terlizzese P , Grande D , Rizzo C , Lattarulo MS , Leopizzi T , Gioia I , Angelo Giagulli Vito , Guastamacchia Edoardo , Iacoviello Massimo

Background: Hypothyroidism and low T3 syndrome frequently occur in HF patients.Aim of the study: To evaluate in a large sample of CHF patients the association between thyroid hormone deficiencies and poor outcome.Methods and results: From 2006 to 2015, we screened 712 consecutive CHF outpatients (551 males, 64±14 years, left ventricular ejection fraction (LVEF) 33±10%, NYHA class 2.3±0.6, NTproBNP 2153±4696 pg/m...
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ea0084op-06-28 | Oral Session 6: Hypothyroidism | ETA2022

The optimal ranges of thyroid function based on the risk of cardiovascular disease and mortality: an individual participant data meta-analysis

Xu Yanning , Derakhshan Arash , Wildisen Lea , Hysaj Ola , Iacoviello Massimo , Ceresini Graziano , Ferrucci Luigi , Iervasi Giorgio , Pingitore Alessandro , Vaes Bert , Gussekloo Jacobijn , Medici Marco , Galesloot Tessel , P. F. Dullaart Robin , J.L. Bakker Stephan , Wouter Jukema J. , Trompet Stella , Westendorp Rudi , Ittermann Till , Volzke Henry , Dorr Marcus , Schmidt Borge , Fuhrer Dagmar , J. Wareham Nicholas , Boelaert Kristien , Razvi Salman , P. J. Vanderpump Mark , Muendlein Axel , Drexel Heinz , Bensenor Isabela , Sgarbi Jose , C. Bauer Douglas , A. Fink Howard , M. Rhee Connie , Azizi Fereidoun , Imaizumi Misa , B. Yeap Bu , Hankey Graeme , J. Brown Suzanne , P. Walsh John , Korevaar Tim , Rodondi Nicolas , R. Cappola Anne , Peeters Robin , Chaker Layal , the Thyroid Studies Collaboration for

Background and Objective: Thyroid function reference ranges are statistically defined by the 2.5th and 97.5th percentiles, which do not account for potential risk of clinical outcomes. We aimed to define the optimal ranges of thyroid-stimulating hormone (TSH) and free thyroxine (FT4), based on the risk of cardiovascular disease (CVD) and mortality.Methods: We performed an individual-participant data analysis and identified prospecti...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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