Endocrine Abstracts

Introduction: Obesity is a major risk factor for mortality from a range of causes. We investigated whether skinfold measurements predict mortality independently of variation in body mass index (BMI).Methods: A prospective analysis of mortality in 870 apparently healthy adult Caucasian men participating in an occupational health cohort was undertaken. At baseline, skinfold measurements were taken at biceps, triceps, iliac and ...

Introduction: Obesity is a major risk factor for mortality from a range of causes. We investigated whether skinfold measurements predict mortality independently of variation in body mass index (BMI).Methods: A prospective analysis of mortality in 870 apparently healthy adult Caucasian men participating in an occupational health cohort was undertaken. At baseline, skinfold measurements were taken at biceps, triceps, iliac and ...

Background: ‘Glycaemic tracking’ describes the stability of HbA1c over time commonly observed in individuals with type 1 diabetes (T1DM). Preliminary studies have noted the relationship between early metabolic control and long-term outcomes, while recent evidence has been presented for glycaemic tracking in a large number of newly diagnosed individuals with T1DM. The benefits of tight glycaemic control, in terms of reducing microvascular complications and lowering Hb...

Introduction: Inconsistent data exist as to whether menopause is associated with increased cardiovascular disease (CVD) risk. However, few studies have evaluated differences in apolipoprotein metabolism according to menopausal status and gender. The aim of this study was to investigate the effects of gender and menopause on serum apolipoprotein B (apoB), A-I (apoA-I) and A-II (apoA-II) concentrations.Methods/design: A cross-sectional analysis was underta...

Background: Increased adiposity is associated with increased cardiovascular disease (CVD) risk but among overweight individuals clarification is needed of relationships between insulin sensitivity, fat distribution and metabolic health that might contribute to this risk.Methods: During the Heart Disease and Diabetes Research Indicators in a Screened Cohort (HDDRISC) study, 560 employment cohort normoglycaemic (FPG less than 7...

Background: Increased adiposity is associated with increased cardiovascular disease (CVD) risk but among overweight individuals clarification is needed of relationships between insulin sensitivity, fat distribution and metabolic health that might contribute to this risk.Methods: During the Heart Disease and Diabetes Research Indicators in a Screened Cohort (HDDRISC) study, 560 employment cohort normoglycaemic (FPG less than 7...

Background: Increased cardiovascular mortality and evidence of atherosclerosis have been reported in patients with pituitary disorders, irrespective of type of pituitary hormone deficiency. However, there are few data on cardiovascular events in patients with secondary adrenal failure due to pituitary disease compared with those who have primary adrenal failure.Subjects: 2052 patients with primary adrenal failure were compared with 20 366 matched control...

Introduction: Data on the effect of hormone replacement therapy (HRT) and tibolone on lipoprotein(a) (Lp(a)), an independent risk factor for cardiovascular disease, are heterogeneous and conflicting. The aim of this study was to investigate the effect of HRT and tibolone on Lp(a) concentrations in post-menopausal women.Methods/design: MEDLINE, Scopus, EMBASE and Cochrane databases were searched (up to February 2016). Two researchers identified randomized...

Introduction: It is not known if non-alcoholic fatty liver disease (NAFLD) predates type 2 diabetes. We will study the prevalence of NAFLD in women with previous gestational diabetes (GDM), a population at ≥60% risk for the development of type 2 diabetes, while glucose tolerance is non-diabetic. It is not known if hepatic fat accumulation in NAFLD is disproportionate to fat accumulation in other tissues. We aim to study the association between fat in the liver and in tis...

BackgroundWhilst hydrocortisone is standard glucocorticoid replacement therapy in patients with adrenal insufficiency, some have considered prednisolone an alternative. Some data have shown diabetes and osteoporosis risk. Mortality of patients using prednisolone in relation with those using hydrocortisone is not known. We compared all-cause mortality risk compared to matched controls in patients with primary or secondary adrenal insufficiency using predn...