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Endocrine Abstracts

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ea0003p5 | Bone | BES2002

Changes in parathyroid hormone sensitivity and rhythmicity and its effects on bone metabolism following growth hormone replacement in adult growth hormone deficient patients

Ahmad A , White H , Thomas J , Clewes A , Hopkins M , Guzder R , Ibrahim H , Durham B , Vora J , Fraser W

BACKGROUND: Adult Growth Hormone Deficiency (AGHD) is associated with reduced bone mineral density (BMD). PTH plays an important role in bone metabolism and reports have suggested target cell insensitivity to PTH as a contributor to the changes in bone turnover seen in AGHD. Although growth hormone replacement (GHR) increases BMD, the underlying mechanisms remain unclear.OBJECTIVES: To determine the effect of GHR on 24-hour PTH profiles, phosphocalcium ...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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