Endocrine Abstracts

We present the case of a 50-year-old woman who presented with 12 months of amenorrhea associated with signs of virilisation. Investigations revealed markedly raised serum concentrations of testosterone (9 nmol/l), whereas sex hormone binding globulin, random cortisol, androstenedione, 17-hydroxyprogesterone and dehydroepiandrosterone sulphate concentrations were all within the normal range. Computed tomography scan of the pelvis and abdomen showed a slightly bulky right ovary,...

Aims: Despite the plethora of testosterone therapies, Successful testosterone replacement remains a challenge. We assessed patient empowerment, treatment satisfaction and adherence to current testosterone replacement guidelines.Methods: Data were collected from case notes and a testosterone diary questionnaire in 16-patients with testosterone deficiency.Results: Median age was 46-years (range 21–69). All patients received an e...

Introduction: Myxoedmea coma is an extreme expression of hypothyroidism with a high mortality rate. It is rarely associated with thyroid lymphoma.Case report: A 66-year-old lady presented acutely unwell with a two week history of cough and shortness of breath. She was hypothermic, hypoxic with clinical and radiological signs of pneumonia. Her TSH was 99.8 mU/L and T4 less than 5 pmol/L with strongly positive thyroid microsomal antibodies, raised WBC and ...

The prevalence of Metabolic Associated Steatotic Liver Disease (MASLD) is approximately 55% in patients with Type 2 diabetes (T2DM). The EASL-EASD-EASO guidelines recommend screening patients with T2DM for MASLD. Fibrosis-4 Index (FIB-4) is a simple tool used to screen for MASLD in T2DM. FIB-4 scores are characterised as; low (<1.3), moderate (1.3 – 2.67) or high risk (>2.67). The aim of the audit was to screen a consecutive number of patients attending the out-pa...

Limited data are available on the effect of transsphenoidal surgery using the endoscopic method on pituitary function. In this preliminary report we retrospectively evaluated the frequency of pituitary failure and recovery in a population of patients who underwent this procedure over a 12 months period. 42 (21 women) consecutive adult patients were included. 29 patients had non-secretory pituitary neuroendocrine tumours, the rest had secretory tumours and other non-adenomatous...