Searchable abstracts of presentations at key conferences in endocrinology

ea0035s1.1 | Endocrine changes and treatment needs in critically ill patients | ECE2014

Thyroid dysfunction in critically ill patients: to treat or not to treat?

Iervasi Giorgio

The low-triiodothyronine (T3) syndrome, also referred as non thyroidal illness, is a frequent finding usually associated to a wide constellation of both acute and chronic extra-thyroid critical disorders that largely differ each other in terms of aetiology, organ involvement, evolution, and clinical impact. Independently of its origin, severity and time-course, the low-T3 syndrome has been always considered an adaptive and positive process not needing spe...

ea0032p991 | Thyroid (non-cancer) | ECE2013

Quantification of tissue T3 and T4 in rat and human heart by a novel HPLC-MS/MS method

Saba Alessandro , Colligiani Daria , Nannipieri Monica , Kusmic Claudia , Dos Remedios Cristobal , Simonides Warner , Iervasi Giorgio , Zucchi Riccardo

Thyroid hormone (T3) is mostly produced in peripheral tissues by thyroxine (T4) deiodination, and its functional effects are directly related to tissue concentration, which is quite difficult to assay by conventional immunological methods. We report a novel technique, based on tandem mass spectrometry (MS/MS) coupled to HPLC, which was used in left ventricular myocardium obtained from rat and human hearts.Samples were homogenized in...

ea0084op-06-28 | Oral Session 6: Hypothyroidism | ETA2022

The optimal ranges of thyroid function based on the risk of cardiovascular disease and mortality: an individual participant data meta-analysis

Xu Yanning , Derakhshan Arash , Wildisen Lea , Hysaj Ola , Iacoviello Massimo , Ceresini Graziano , Ferrucci Luigi , Iervasi Giorgio , Pingitore Alessandro , Vaes Bert , Gussekloo Jacobijn , Medici Marco , Galesloot Tessel , P. F. Dullaart Robin , J.L. Bakker Stephan , Wouter Jukema J. , Trompet Stella , Westendorp Rudi , Ittermann Till , Volzke Henry , Dorr Marcus , Schmidt Borge , Fuhrer Dagmar , J. Wareham Nicholas , Boelaert Kristien , Razvi Salman , P. J. Vanderpump Mark , Muendlein Axel , Drexel Heinz , Bensenor Isabela , Sgarbi Jose , C. Bauer Douglas , A. Fink Howard , M. Rhee Connie , Azizi Fereidoun , Imaizumi Misa , B. Yeap Bu , Hankey Graeme , J. Brown Suzanne , P. Walsh John , Korevaar Tim , Rodondi Nicolas , R. Cappola Anne , Peeters Robin , Chaker Layal , the Thyroid Studies Collaboration for

Background and Objective: Thyroid function reference ranges are statistically defined by the 2.5th and 97.5th percentiles, which do not account for potential risk of clinical outcomes. We aimed to define the optimal ranges of thyroid-stimulating hormone (TSH) and free thyroxine (FT4), based on the risk of cardiovascular disease (CVD) and mortality.Methods: We performed an individual-participant data analysis and identified prospecti...