Searchable abstracts of presentations at key conferences in endocrinology

ea0035p1083 | Thyroid Cancer | ECE2014

Langerhans cell histiocytosis and papillary thyroid carcinoma

Biagetti Betina , Diego Estrella , Dalama Belen , Iglesias Carmela , Gonzalez Oscar , Mesa Jordi

Introduction: Thyroid gland involvement by Langerhans Cell Histiocytosis (LCH) is a very rare condition. It occurs by thyroid infiltration that may result in hypothyroidism. LCH may be also related to neoplastic processes such as leukemias or lymphomas. However, the association with papillary thyroid carcinoma (PTC) is exceptional. We introduce a case and review the reported cases of this association.Case report: We describe a 33 year old patient diagnos...

ea0073pep5.7 | Presented ePosters 5: Thyroid | ECE2021

Multifocality in papillary thyroid carcinoma. Is it always the same tumor?

Efrain Cordero-Vazquez. , Iglesias Carmela , Sesé Marta , Somoza Rosa , Javier Hernandez-Losa , Zafon Carles

IntroductionMultifocality is a common finding in papillary thyroid carcinoma (PTC), but its biological significance is not well established. In some cases not all foci present the same histological pattern.ObjectiveTo study the different histological patterns and molecular profiles of multifocal PTC (mPTC).Material and methodsAll patients with a confirmed diagnosi...

ea0041gp223 | Thyroid Cancer | ECE2016

Macro, but not micrometastases, detected by OSNA technique are related with more aggressive papillary thyroid cancer features

Zafon Carles , Iglesias Carmela , Gonzalez Oscar , Temprana Jordi , Caubet Enric , Garcia-Burillo Amparo , Obiols Gabriel , Serres Xavier , Mesa Jordi

Introduction: Classically, risk stratification in papillary thyroid carcinoma (PTC) assigned the same magnitude of risk to all patients with regional lymph node involvement (N1 disease). However, specific lymph node characteristics (such as size, number, extension, etc.) will allow individualizing treatment and follow-up. One-Step Nucleic Acid Amplification (OSNA) measures the number of copies of mRNA of cytokeratin 19 (CK19) as a marker of lymph node metastasis. Thus, copy nu...

ea0092op-05-02 | Oral Session 5: Young Investigators / Basic | ETA2023

Thyroid tumor microenvironment: deconvolution of tumor composition using DNA methylation data

Rodriguez-Lloveras Helena , Carmela Iglesias , Klein Hesselink Esther , Lluis Reverter Jordi , Links Thera , Carles Zafon , Jorda Mireia

Introduction: Most thyroid cancer (TC) patients have a good prognosis, but some of them show aggressive behavior and are resistant to treatment. Still no effective biomarkers are available to predict which patients will progress. Epigenetic alterations are a hallmark of cancer, and profiling DNA methylation has allowed a better understanding of the epigenetic landscape of TC and its influence in TC progression. However, bulk DNA methylomes include information not only from tum...

ea0041ep262 | Clinical case reports - Pituitary/Adrenal | ECE2016

Left adrenal Ectopic cushing syndrome even more challenging

Biagetti Betina , Simo Olga , Ortiz Angel , Iglesias Carmela , Dalama Belen , Obiols Gabriel , Castell-Conesa Joan , Gracia-Burillo Amparo , Caubet Enric , Mesa Jordi

Background: The Ectopic ACTH Syndromes (EAS) often associated with severe hypercortisolism are really a challenge.Case presentation: We report the case of a 48-year-old woman, newly diagnosed with hypertension, hypokalemia despite renin-angiotensin blockers intake, and complaints of intense fatigue, muscular weakness, and easy bruising, which worse in four months. EAS was biochemically confirmed, but two urinary catecholamines collection were negatives d...

ea0037gp.24.04 | Thyroid–genetics | ECE2015

Lymph node involvement using one-step nucleic acid amplification according to BRAF gene mutation status in patients with papillary thyroid carcinoma submitted to lymph node dissection

Zafon Carles , Gonzalez Oscar , Temprana Jordi , Obiols Gabriel , Garcia-Burillo Amparo , Serres Xavier , Balibrea Jose Maria , Castell Joan , Mesa Jordi , Iglesias Carmela

Introduction: The relationship between the BRAF gene mutation in papillary thyroid cancer (PTC) and the presence of lymph node metastasis (LNM) is a subject of controversy.Objective: To analyse the influence of BRAF mutation status in the characteristics of lymph nodes in patients with PTC submitted to lymph node dissection (LND).Material and methods: Lymph nodes obtained from 20 patients (12 females, mean age 50±15 y...

ea0056oc9.4 | Thyroid from basics to clinics | ECE2018

Identification of an epigenetic biomarker panel for predicting the development of distant metastases in differentiated thyroid cancer

Rodriguez Helena , Zafon Carles , Villalmanzo Nuria , Cerda Lorena , Iglesias Carmela , Real Jordi , Gil Joan , Hesselink Esther N. Klein , van Hemel Bettien M. , Montero-Conde Cristina , Reverter Jordi L. , Mauricio Didac , Puig-Domingo Manel , Robledo Mercedes , Links Thera P. , Jorda Mireia

Background: Differentiated thyroid cancer (DTC) is usually associated with an excellent prognosis. The main cause of death is due to distant metastases, but distant metastatic DTC (dmDTC) presents an interpatient heterogeneity. Some patients with distant metastases live with stable disease for many years, while others die very early. Still no effective biomarkers are available to predict either which patients will eventually develop distant metastases or what will be the final...

ea0070aep863 | Thyroid | ECE2020

Retrospective incidence of NIFTP. A large multicentre Iberic study of over 3000 neoplasms

Paja Miguel , Rosa Bella M. , Iglesias Carmela , Zafón Carles , Cameselle Jose M.l , Carnero Gemma , Póvoa Antónia , Ugalde Aitziber , Anda Emma , Fernández-Seara Pilar , Sánchez-Gómez Nancy M. , Quiceno Hernán , García-Pascual Lluis , González Clarisa , Blanco Concepción , Gómez de la Riva Inés , Capel Ismael , Mancha Isabel , Gallego Helena , Maravall Javier , Roselló Esther , Alcázar Victoria , Chao Montserrat , Lázaro Antonia , Lopez-Agulló Susana , Echeverría Saioa , Joaquín Paricio J. , Sanz Javier , Messeguer Pascual , Castaño Ángel

The newly created NIFTP category (non-invasive follicular thyroid neoplasm with papillary-like nuclear features) has had a notorious impact in the management of thyroid neoplasms. Its incidence appears to be higher in western countries than Asiatic, but there are few studies including more than one institution.Objectives: To evaluate retrospectively the incidence of NITFP in a multicentre study in two adjacent countries as well as to compare th...