Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep112 | Clinical case reports - Pituitary/Adrenal | ECE2017

Paraganglioma (PG) and cyanotic congenital heart disease (CCHD): the role of tisular hypoxia

Oleaga Amelia , Goni Fernando , Paja Miguel , Ugarte Estibaliz , Moreno Cristina , Iglesias Natalia , Etxeberria Eider , Calles Laura , Dublang Maddalen , Zabalegui Alba

Introduction: CCHD comprises a number of different congenital heart defects associated with elevated pulmonary artery pressure and pulmonary vascular resistance, resulting in a reversed or bidirectional shunt (Eisenmenger syndrome). These entities develop systemic hypoxia. Pheochromocytoma and paraganglioma (PHEO/PG) are neuroendocrine tumours. Several inheritance genetic alterations have been reported in PHEO/PG syndromes. A pathogenic association between these entities is pr...

ea0049ep1040 | Pituitary - Clinical | ECE2017

Radiological study of clinically non-functioning pituitary macroadenomas: a single institutional experience

Moreno Cristina , Paja Miguel , Lizarraga Aitzol , Etxeberria Eider , Arrizabalaga Cristina , Ugarte Estibaliz , Izuzquiza Ana , Goni Fernando , Iglesias Natalia , Calles Laura

Introduction: When facing with non-functioning pituitary macroadenomas (NFPMA), radiological invasion is determinant to surgical approach, apart from histological biomarkers of pituitary tumor aggressiveness (Ki-67; p53 and mitotic index). Invasive tumors usually need additional surgery and/or radiotherapy. There are no much studies describing epidemiological data on aggressive pituitary tumors in clinical practice. We provide information regarding the radiological findings of...

ea0032p1126 | Thyroid cancer | ECE2013

BRAF V600E mutation in papillary thyroid cancer: clinical and pathological features. Is there any role in tailoring initial treatment?

Oleaga Amelia , Goni Fernando , Paja Miguel , Iglesias Natalia , Fuertes Elena , Lizarraga Aitzol , Palacios Angel Gomez , Elorza Ramon

Introduction: BRAF (V600E) mutation is the most frequent detected genetic change in papillary thyroid cancer (PTC) and its presence has been related to aggressive clinical and pathological features. Lymph node metastases (LNMx) are common in PTC and are associated with an increase in loco-regional recurrence. However, prophylactic lymph node dissection is not routinely performed because of high rate of surgery complications. Therefore, there is a need to find a good marker to ...

ea0063p89 | Calcium and Bone 1 | ECE2019

Diagnostic and treatment delay in primary hyperparathyroidism (phpt): a pending issue

Paja Miguel , Martinez Adela L , Monzon Andoni , Arrizabalaga Cristina , Zabalegui Alba , Iglesias Natalia C , Calles Laura A , Etxeberria Eider M , Gutierrez Teresa

Background: PHPT is the leading cause of hypercalcemia in outpatients. Its clinical presentation varies from asymptomatic forms to renal or bone complications. The only curative treatment is surgical resection, and delayed diagnosis can lead to serious morbidity.Objective: Identify the presence of PHPT at least one year prior to referral to endocrinology consultation. Secondly, determine whether diagnostic delay leads to increased complications.<p cl...

ea0063p405 | Thyroid 1 | ECE2019

Radiofrequency ablation in the treatment of benign thyroid nodules: a good alternative to surgery

Moreno Cristina , Paja Miguel , Izuzquiza Ana , Espiga Javier , Arrizabalaga Cristina , Martinez Adela Leyre , Monzon Andoni , Zabala Rosa , Iglesias Natalia , Calles Laura

Introduction: To date, benign thyroid nodules complainig of symptomatic or cosmetic problems and autonomous functioning thyroid nodules (AFTN) have generally been treated with surgery or I131. Radiofrequency ablation (RFA) is a novel technique that has demonstrated safety and efficacy in the treatment of these nodules. We describe the clinical experience at our hospital.Material and method: We include 33 patients (28 women, 5 men) from January 2013 to Se...

ea0049ep1217 | Clinical case reports - Thyroid/Others | ECE2017

Simultaneous papillary and medullary thyroid carcinoma in siblings with RET 611 mutation. More than a coincidence?

Paja Miguel , Zabalegui Alba , Dublang Maddalen , Etxeberria Eider , Iglesias Natalia C , Calles Laura A , Arrizabalaga Cristina , Lizarraga Aitzol , Gutierrez M Teresa , Ugalde Aitziber

Germinal mutations of the oncogene RET originate the development of medullary thyroid carcinoma (MTC) in carriers with phenotypic expression depending on the mutated codon and other unknown factors. Simultaneous detection of differentiated thyroid carcinomas is considered a casual phenomenon (collision tumours). We communicate two brothers with double heterozygous mutation of maternal inheritance at codon 611 of RET, TGC to TTT, changing to encode phenylalanine (C611F), with a...

ea0070aep142 | Bone and Calcium | ECE2020

The prevalence of postoperative (PO) chronic hypoparathyroidism (HypoPTH) in bilbao, northern spain

Oleaga Amelia , Goñi Fernando , Moreno Cristina , Iglesias Natalia , Calles Laura , Monzon Andoni , Martinez Adela , Merlo Ignacio , Gutierrez Teresa , Ruiz de Velasco Elena , Paja Miguel

Introduction: HypoPTH is an uncommon disorder, mostly due to anterior neck surgery. The prevalence of HypoPTH has been studied in surgical series and registries, (USA, Denmark and Hungary) where only a minority of patients has HypoPTH due to non-surgical causes. In Spain data on PO HypoPTH in endocrinologist clinical practice has been published recently. The aim of this study was to establish the prevalence of chronic PO HypoPTH in Bilbao area, with a population 2019: 346,843....

ea0032p123 | Calcium and Vitamin D metabolism | ECE2013

Early measure of postoperative iPTH and corrected calcium as predictors of future hypoparathyroidism: which, when and why?

Paja Miguel , Moreno Cristina , Ugarte Estibaliz , Oleaga Amelia , Gutierrez Ma Teresa , Izuzquiza Ana J , Etxeberria Eider , Iglesias Natalia C , Lizarraga Aitzol , Martinez-Mate Maria P

Introduction: Intraoperative parathyroid hormone assay (ioPTH) has been validated as a useful tool for predicting postoperative hypocalcaemia (hypoCa) after thyroid surgery and has been proposed as a guide to early discharge from hospital. Its value to predict the risk of future hypoparathyroidism (hypoPT) has not been analyzed in detail. We evaluate this role in our recent surgical series.Description of methods/design: Patients with total thyroidectomy ...

ea0056p1157 | Thyroid cancer | ECE2018

Serum thyroglobulin (sTg) before surgery in euthyroid patients with differentiated thyroid cancer (DTC)

Paja Miguel , Lizarraga Aitzol , Exposito Amaia , Teresa Gutierrez M , Barrios Borja , Iglesias Natalia C , Zabalegui Alba , Arrizabalaga Cristina , Martinez Adela L , Oleaga Amelia

sTg is universally accepted as the best marker of disease status in DTC. Its presurgical serum level may suggest the presence of distant metastasis in case of very high level, but the correlation between its level and the characteristics of the tumour is yet to be defined.Objective: To evaluate preoperative thyroglobulin as predictor of DCT features.Methods: Preoperative sTg was measured in patients operated for DTC between 2011&#1...