Endocrine Abstracts

Introduction: Ectopic parathyroid adenoma is a rare cause of primary hyperparathyroidism, it accounts for 10% of parathyroid adenomas.Observation: A 56 years old man with no past medical history developed sudden acute renal failure after few weeks of fatigability, polydypsia and emesis. Hypercalcemia of 4.20 mmol/l (2.2–2.5 mmol/l), serum creatinine of 306 mmol/l, hypophospatemia 0.72 mmol/l (0.80–1.5 mmol/l) and high alkaline phosphatase 205 I...

Introduction: The carcinoid heart disease is an uncommon valvular heart disease that may occur in carcinoid syndrome.Valvulopathy is reported in 50% to 70% of patients of carcinoid syndrome, due to the release of serotonin secreted by metastatic cells in the liver, reaching directly right side of heart. The left side is preserved because of inactivation of serotonin by lung parenchyma. Hypoxemia is an unusual presentation of the carcinoid heart disease.C...

Introduction: Thyroid lymphoma is a rare thyroid disease, occurring mostly in the elderly. We report a series of 13 cases from a single centre.Material and methods: Among our regional registry (1294 cases of thyroid cancer), we report 16 cases of thyroid lymphoma (with sufficient data on follow up for 13).Results: Mean age was 68.3 years (range 38–85) and included 12 women for 1 man. Nine patients also presented with Hashimoto...

Acute suppurative thyroiditis is a rare disease because thyroid gland is highly resistant to infection. The most common predisposing factor is the presence of a piriform fistula. We report an unusual case of hyperthyroidism caused by AST.A 27-year-old woman was admitted to our hospital because she presented a painful swelling in the left thyroid gland with fevers. Laboratory test showed a white leukocyte count of 14 000/μl, a CRP level of 251 mg/l, ...

The prognosis of thyroid anaplastic carcinoma is poor. Yet can prognosis criteria change the therapeutic options?Method: From a series of 26 cases from a single group recorded between 1990 and 2006, we analyzed the outcome after treatment based on surgery, radio and chemotherapy and looked for prognosis criteria.Results: All but one patients died with a mean survival of 273 days (median survival of 130 days). Over 50% of patients h...

Objective: Maxillofacial manifestations of acromegaly are well described (prognathism, inter-dental space enlargement, occlusion disorder, macroglossia, prominent cheekbones…) [1] but the dental and periodondal impact of this disease has been poorly investigated. The scientific literature on this topic is scarce, with controversies about gingival and cement enlargement. Our goal is to describe the oro-dental state of these patients as precisely as possible and to study t...

Introduction: Dyslipidemia and impaired fertility are highly related. In animals, statin intake reduces sperm parameters deterioration associated with hypercholesterolemia. However, statin effects on human fertility are controversial. Their intake by hypercholesterolemic patients could reduce circulating testosterone concentration and sperm quality. While recommendations for cardiovascular prevention advocate lowering total cholesterol and LDL-C, atorvastatin, the most prescri...

A 56 years old woman was admitted to an intensive Care Unit for generalized seizure seven days following total thyroidectomy for toxic multinodular goiter. Thyroidectomy included self transplantation of a right parathyroid gland. Pathologic analysis confirmed benign multinodular goiter, without parathyroid tissue. Post operatively, on LT4 therapy, follow up symptoms included facial paresthesia associated to mild hypocalcaemia (1.56 mmol/l) at day 2, treated with ora...

A 63-year-old woman was referred by her cardiologist because of rapid growth of an anterior cervical mass. The patient had a history of severe vascular atherosclerotic disease, requiring multiple prosthetic vascular surgery, among which thoracic aorta surgery, atrial fibrillation requiring coumadin and chronic respiratory failure. On admission, the patient presented with a 7 cm firm mass, regularly growing for 2 months, adherent to the cervical skin, highly suggestive of thyro...

Thyroid anaplastic carcinoma (TAC) is rare among thyroid cancers. Few surveys on these diseases are available.Aim: To analyze the clinical and pathological characteristics of TAC in Auvergne, France, from a series of 26 patients among a cohort of over 1500 thyroid carcinomas (i.e. 1.7% of total thyroid cancers).Results: Mean age was 72.1 years (range 42–91 years), with a sex ratio of 19 women to 7 men. A previous history of th...