Searchable abstracts of presentations at key conferences in endocrinology

ea0070ep94 | Bone and Calcium | ECE2020

Effect of Denosumab on bone mineral density of hematopoietic stem cell transplantation recipients

Ha Jeonghoon , Kang Moo Il

Purpose: Denosumab is a monoclonal antibody that prevents osteoclast development. The effect of denosumab in solid organ transplant recipients has been elucidated, but the effect of denosumab in hematopoietic stem cell transplantation recipients has not been studied yet. Thus, the aim of this study was to determine the effectiveness and safety of denosumab in hematopoietic stem cell transplantation recipients.Methods: We retrospectively evaluated 27 pati...

ea0008p70 | Neuroendocrinology and behaviour | SFE2004

Blood Cerebrospinal Fluid Barrier (BCB) for TSH, Prolactin and Insulin in Pregnancy

Lutescu I , Gussi IL , Banceanu G , Coculescu M

The blood-brain barrier for peptide hormones is protective for the maternal brain.OBJECTIVE: To compare peptide hormone levels on the two sides of the blood cerebrospinal fluid barrier in pregnant, non pregnant and menopausal women.METHODS: We investigated, with the approval of the local ethics committee, 35 healthy pregnant women at term, aged 21-41 years (group G), 27 non-pregnant women aged 21-43 years (group C) and 15 menopausa...

ea0056p1171 | Thyroid cancer | ECE2018

Natural course of thyroid cancer nodules compared with benign thyroid nodules

Baek Ki-Hyun , Kang Moo-Il , Yoon Kyung-Jin

Purpose: The primary aim of this study was to evaluate changes in the diameter and volume of thyroid cancer nodules identified using fine-needle aspiration biopsy (FNAB) or surgery, and to compare the changes in size between thyroid cancer nodules and benign nodules. The secondary aim was to analyze the risk factors associated with thyroid cancer nodule growth.Methods: A total of 96 patients with 102 nodules were enrolled in the cancer group, and 98 pati...

ea0081ep790 | Pituitary and Neuroendocrinology | ECE2022

Sarcopenia and frailty in acromegalic patients

Ugur Kader , Eryeşil Hasan , Fazıl Akkoc Ramazan , Karatas Ahmet

Introduction: Acromegaly is a clinical syndrome associated with excess growth hormone. The present study aimed to investigate sarcopenia and frailty, which could affect mortality and morbidity, in patients with acromegaly.Method: Twenty outpatients diagnosed with acromegaly were included in the study. The hand muscle strength of the patients was measured by electronic hand dynamometer (Model EH101, Zhongshan Camry Electronic Co. Ltd. China). Computed tom...

ea0084ps1-03-23 | Thyroid Cancer CLINICAL 1 | ETA2022

Comparison between minimal and gross ete for risk of recurrence in papillary thyroid carcinoma : a propensity score matching study

Park Joonseon , ku kang il , Kim Kwangsoon , Seong Bae Ja , kim jeongsoo

Background: The presence of extathyroidal extension (ETE) is associated with locoregional recurrence and distant metastases in papillary thyroid carcinoma (PTC). ETE is classified into gross ETE (gETE) and minimal ETE (mETE). The mETE was recently excluded from the T3 category in the TNM staging system. The purpose of this study is to compare the recurrence risk of mETE and gETE in PTC patients through propensity score matching analysis. And a comparison in the same way for pa...

ea0011p890 | Thyroid | ECE2006

Immunohistochemical staining for thyroid peroxidase (TPO) of tru-cut biopsies from scintigraphically cold thyroid nodules

Yousaf UY , Christensen LC , Rasmussen AKR , Jensen FJ , Hilmer EH , Mollerup CM , Kirkegaard JK , Lausen IL , Feldt-Rasmussen UFR

Background: Scintigrafically cold nodules are hypofunctioning areas in the thyroid gland. These nodules are common and as the risk of malignancy is low, surgery is only necessary in very few cases. Fine Needle Aspiration Cytology (FNAC) is the standard method for detecting malignant tumours. However, FNAC is a difficult diagnostic procedure which often gives insufficient working material.Materials and methods: A prospective study was designed to calculat...

ea0038p9 | Bone | SFEBES2015

The decreased plasma levels of sclerostin but not Dickkopf-1 are associated with increased risk of osteoporotic fracture and lower bone mineral density in Korean postmenopausal women

Lim Yejee , Koh Jung-Min , Kim Beom-Jun , Kang Moo-Il , Lee Seung Hun , Baek Ki Hyun , Rhee Yumie , Min Yong-Ki , Kim Deog-Yoon , Kim Chong Hwa

Background: Although sclerostin (SOST) and Dickkopf-related protein 1 (DKK1) are major regulators in bone metabolism, the associations between these soluble Wnt antagonists and osteoporotic fracture (OF) in Asians, who may have distinct biologic characteristics with Caucasians, are inconclusive. Furthermore, there have been no clinical studies separately considering non-vertebral and vertebral fractures in terms of the blood levels of SOST and DKK1.Metho...

ea0056oc3.1 | New insights in bone disorders | ECE2018

A Phase 3 randomized, double-blind, placebo-controlled study investigating the efficacy and safety of Burosumab, an anti-FGF23 antibody, in adult X-Linked Hypophosphatemia (XLH)

Kamenicky Peter , Lachmann Robin , Carpenter Thomas O. , Cohen-Solal Martine , Eastell Richard , Brandi Maria Luisa , Crowley Rachel K. , Ralston Stuart H. , Javaid Muhammad K. , Keen Richard , Briot Karine , Il Cheong Hae , Imanishi Yasuo , Ito Nobuaki , Tanaka Hiroyuki , Zhang Lin , Theodore-Oklota Christina , Mealiffe Matt , Martin Javier San , Insogna Karl L.

UX023-CL303 is an ongoing, Phase 3, double-blind, multicenter study examining the efficacy and safety of burosumab, a fully human monoclonal antibody against FGF23, in adults with XLH. Eligible subjects had serum phosphorus levels <0.81 mmol/l and skeletal pain (BPI – Worst Pain ≥4). Subjects (N=134) were randomized 1:1 to receive burosumab 1 mg/kg or placebo subcutaneously every 4 weeks. After 24 weeks, subjects in the placebo group crossed-over to rec...