Endocrine Abstracts

Purpose: Denosumab is a monoclonal antibody that prevents osteoclast development. The effect of denosumab in solid organ transplant recipients has been elucidated, but the effect of denosumab in hematopoietic stem cell transplantation recipients has not been studied yet. Thus, the aim of this study was to determine the effectiveness and safety of denosumab in hematopoietic stem cell transplantation recipients.Methods: We retrospectively evaluated 27 pati...

The blood-brain barrier for peptide hormones is protective for the maternal brain.OBJECTIVE: To compare peptide hormone levels on the two sides of the blood cerebrospinal fluid barrier in pregnant, non pregnant and menopausal women.METHODS: We investigated, with the approval of the local ethics committee, 35 healthy pregnant women at term, aged 21-41 years (group G), 27 non-pregnant women aged 21-43 years (group C) and 15 menopausa...

Purpose: The primary aim of this study was to evaluate changes in the diameter and volume of thyroid cancer nodules identified using fine-needle aspiration biopsy (FNAB) or surgery, and to compare the changes in size between thyroid cancer nodules and benign nodules. The secondary aim was to analyze the risk factors associated with thyroid cancer nodule growth.Methods: A total of 96 patients with 102 nodules were enrolled in the cancer group, and 98 pati...

Introduction: Acromegaly is a clinical syndrome associated with excess growth hormone. The present study aimed to investigate sarcopenia and frailty, which could affect mortality and morbidity, in patients with acromegaly.Method: Twenty outpatients diagnosed with acromegaly were included in the study. The hand muscle strength of the patients was measured by electronic hand dynamometer (Model EH101, Zhongshan Camry Electronic Co. Ltd. China). Computed tom...

Background: The presence of extathyroidal extension (ETE) is associated with locoregional recurrence and distant metastases in papillary thyroid carcinoma (PTC). ETE is classified into gross ETE (gETE) and minimal ETE (mETE). The mETE was recently excluded from the T3 category in the TNM staging system. The purpose of this study is to compare the recurrence risk of mETE and gETE in PTC patients through propensity score matching analysis. And a comparison in the same way for pa...

Post-thyroidectomy syndrome is defined as postoperative problems after thyroidectomy without injury of recurrent laryngeal nerve, and including most common symptom such as vocal fatigue, loss of high-pitch, reduced vocal strength, reduced speaking fundamental frequency also can be presented. In a recent systemic review, F0, shimmer, and MPT was significantly deteriorated only in the early period and not in the late period after thyroidectomy. There have been several questionna...

Background: Scintigrafically cold nodules are hypofunctioning areas in the thyroid gland. These nodules are common and as the risk of malignancy is low, surgery is only necessary in very few cases. Fine Needle Aspiration Cytology (FNAC) is the standard method for detecting malignant tumours. However, FNAC is a difficult diagnostic procedure which often gives insufficient working material.Materials and methods: A prospective study was designed to calculat...

Background: Although sclerostin (SOST) and Dickkopf-related protein 1 (DKK1) are major regulators in bone metabolism, the associations between these soluble Wnt antagonists and osteoporotic fracture (OF) in Asians, who may have distinct biologic characteristics with Caucasians, are inconclusive. Furthermore, there have been no clinical studies separately considering non-vertebral and vertebral fractures in terms of the blood levels of SOST and DKK1.Metho...

Introduction: Hashimoto’s thyroiditis (HT) is caused by a variety of genes, cytokines, receptors, and environmental factors. A series of enzymes known as type 1 and type 2 deiodinases (D1, D2) are in charge of converting thyroxine (T4) into triiodothyronine (T3). It is believed that the low free T3 (fT3) levels caused by D2 polymorphism may result in thyroid autoimmunity through the induction of inflammation. However, iodothyronine deiodinase (DIO) gene polymorphism and H...

Introduction: Renin-angiotensin-aldosterone system was shown to be activated in severe COVID-19 infection. We aimed to investigate the relation between angiotensin converting enzyme (ACE) levels, ACE gene polymorphism, type 2 diabetes (T2DM), and hypertension (HT), and the prognosis of COVID-19 infection.Methods: Clinical features of adult patients with SARS-CoV-2 infection diagnosis were analyzed. ACE gene analysis and ACE level measur...