Searchable abstracts of presentations at key conferences in endocrinology

ea0019p287 | Reproduction | SFEBES2009

Dihydrotestosterone increases KiSS1 expression in adipose and pituitary tissue, but not in hypothalamus, in a rat model of polycystic ovary syndrome (PCOS)

Brown R , Wilkinson D , Imran S , Wilkinson M

The epidemic-like increase in obesity in young people is paralleled by a rise in related diseases such as PCOS, especially in pubertal girls. Kisspeptins, encoded by the KiSS1 gene, are firmly linked with the normal control of the reproductive system and loss-of-function mutations are associated with absence of puberty. Although KiSS1 is predominantly expressed in the hypothalamus (HYP), we detected KiSS1 mRNA in rat pituitary (PIT) and adipose tissue (FAT...

ea0003p193 | Neuroendocrinology | BES2002

Leptin and leptin receptors are developmentally regulated in rat pituitary

Morash B , Imran S , Ur E , Wilkinson M

We reported that leptin mRNA is developmentally regulated and hypothesized that local leptin expression is important for the maturation of the hypothalamic-pituitary system. Pituitary leptin mRNA levels were down-regulated in early postnatal male and female rats. We now show that pituitary leptin protein content and expression of the long (OBRb) and short (OBRa) leptin receptor isoforms in the pituitary and hypothalamus also undergo age-related changes. Tissue wa...

ea0099rc9.7 | Rapid Communications 9: Pituitary and Neuroendocrinology | Part II | ECE2024

Pituitary apoplexy: A retrospective canadian single center cohort study

Parker Ellen , Ali Imran S. , Hebb Andrea , Kureshi Nelofar , Clarke David

Introduction: Pituitary apoplexy is a rare clinical syndrome that often involves headache, visual deficits, and endocrine dysfunction resulting from infarction or hemorrhage of a pituitary tumor. Due in part to the rare nature of this condition, there are few large studies on pituitary apoplexy described in the literature. Here, we present a large single center retrospective cohort study of patients with pituitary apoplexy managed surgically or conservatively.<p class="abs...