Searchable abstracts of presentations at key conferences in endocrinology

ea0081p33 | Calcium and Bone | ECE2022

Psychometric evaluation of the hypoparathyroidism symptom diary using data from two clinical trials

Nelson Lauren , Ing Steven , Rubin Mishaela , Ma Jia , Martin Susan , Sen Rohini , Ayodele Olulade

The Hypoparathyroidism Symptom Diary (HypoPT-SD) was developed for the daily assessment of key symptoms and impact of HypoPT as reported by patients with chronic HypoPT and includes 13-items: a 7-item Symptom subscale, 4-item Impact subscale, and single-item anxiety and depression scores. The current analysis was undertaken to confirm test-retest reliability and construct validity of HypoPT SD Symptom subscale scores using data collected during two open-label, single-arm studi...

ea0049ep291 | Calcium & Vitamin D metabolism | ECE2017

Chronic hypoparathyroidism disease profile from 492 patients in the PARADIGHM™ natural history global registry

Clarke Bart L , Ing Steven , Khan Aliya , Mannstadt Michael , McDermott Michael , Piccolo Rebecca , Shanik Michael H. , Vokes Tamara J , Germak John

PARADIGHM™ is a global registry (NCT01922440) of patients diagnosed with hypoparathyroidism (HPT) ≥6 months regardless of aetiology and management. Routine medical care data were entered using electronic case report forms; the 36-item Short Form Health Survey was completed by patients. Baseline-recorded data are reported for 492 patients enrolled as of 1 December 2016 from 41 centres. At baseline, 78% were women, mean (S.D.) age was 49 (17)...

ea0070aep180 | Bone and Calcium | ECE2020

Baseline characteristics from the observational paradighm registry of patients with chronic hypoparathyroidism

L Clarke Bart , Rejnmark Lars , Ing Steven , Luisa Brandi Maria , Björnsdottir Sigridur , Hahner Stefanie , Hofbauer Lorenz C , Houillier Pascal , Khan Aliya A , Levine Michael A , Mannstadt Michael , M Shoback Dolores , Vokes Tamara J , Zhang Pinggao , Marelli Claudio , Germak John , Gittoes Neil

PARADIGHM is an actively recruiting, prospective, observational registry (NCT01922440/EUPAS16927). The primary objective is to evaluate the safety and effectiveness of recombinant human parathyroid hormone, rhPTH(1-84), treatment in patients with chronic hypoparathyroidism under routine clinical care. The secondary objective is tocharacterize the clinical course of chronic hypoparathyroidism under conditions of routine clinical practice. At enrollment, registry inclusion crite...