Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep1066 | Thyroid (non-cancer) | ECE2016

Hypertrophic Hashimoto’s thyroiditis mimicking thyroid lymphoma

Alexandru Niculescu Dan , Iorgulescu Radu , Dumitrascu Anda , Poiana Catalina

Introduction: Hashimoto’s thyroiditis (HT) is a well known risk factor for thyroid lymphoma. A rapidly enlarging goiter accompanied by lymph nodes pressure on surrounding structures usually suggest the development of thyroid lymphoma.Case report: An 85 years old hypertensive women presented for a massive goiter extending from the lower jaw to clavicle which increased in size for the last 5 months. She also complained of dysphagia, hoarseness and sho...

ea0067gp16 | Poster Presentations | EYES2019

Association of adrenal cortisol-producing adenoma and invasive papillary thyroid carcinoma in an older patient: coincidence or multiple endocrine neoplasia (MEN)?

Iancu Cristina , Gaita Isabela , Tomulescu Victor , Iorgulescu Radu , Capatina Cristina , Radian Serban , Poiana Catalina

Background: Association of differentiated thyroid carcinoma (DTC) and cortisol-producing adrenal adenoma is not part of the classical MEN syndromes. We present a clinical case raising the question of a common etiology for these tumours.Case Presentation: A 58-year-old female presented in 2010 for the investigation of a 6 cm left adrenal tumour incidentally discovered by abdominal CT. Medical history included smoking, obesity, myocardial infarction, hyper...

ea0070aep32 | Adrenal and Cardiovascular Endocrinology | ECE2020

A rare case of functioning adrenocortical oncocytoma of uncertain malignant potential in a young female diagnosed with type 1 neurofibromatosis

Gaita Isabela , Iorgulescu Radu , Cristina Terzea Dana , Danau Razvan , Poiana Catalina , Radian Serban

Background: Adrenocortical oncocytoma is a veryrare adrenal tumor type, usually nonfunctioning and benign. Neurofibromatosistype 1 (NF1) is an autosomal dominant disease caused by mutations of the NF1 gene encoding neurofibromin, a tumor supressor gene that acts by activating a RAS GTP-ase which negatively regulates RAS activity. NF 1 is usually associated with pheocromocytoma, rarely with adrenal carcinoma, and no association with adrenal oncocytoma has been reported.<p c...

ea0099ep721 | Adrenal and Cardiovascular Endocrinology | ECE2024

ACTH-independent cushing’s syndrome in a patient with bilateral adrenal tumors: complete remission after unilateral adrenalectomy

Nicoleta Chetan Larisa , Vladan Andreea , Rebeca Cretoiu , Iorgulescu Radu , Radian Serban , Catalina Poiana

Introduction: Bilateral adrenal tumors in patients with adrenal Cushing’s syndrome (CS) are rare, lending to differential diagnosis which includes bilateral macronodular adrenal disease (BMAD), synchronous adrenal adenomas and even adrenocortical carcinoma. The treatment consists of unilateral adrenalectomy, followed by contralateral adrenalectomy, if warranted by persistent significant CS.Aim: To present a case highlighting unilateral adrenalectomy...

ea0099ep971 | Endocrine-Related Cancer | ECE2024

Secondary amenorrhea – an inconspicuous presentation of sporadic MEN1 syndrome

Monalisa Preda-Ivascu , Iorgulescu Radu , Schipor Sorina , Muresan Andrei , Braha Elena , Radian Serban , Poiana Catalina

Introduction: The MEN1 syndrome is caused by inactivating mutations of MEN1, a tumor suppressor gene encoding menin. A sporadic presentation is relatively rare (8-14%) and could be due to de novo mutations.Aim: To present an MEN1 case diagnosed following a routine consultation for amenorrheaCase presentation: A 44-year-old female presented with secondary amenorrhea and a history of complicated renal lithiasis requiring rep...

ea0059ep14 | Adrenal and steroids | SFEBES2018

Cushing’s syndrome due to primary bilateral macronodular adrenal hyperplasia (PBMAH) - clinical and hormonal characterisation

Vladan Andreea , Radian Serban , Baranga Iuliana , Moraru Catalina , Deciu Diana , Dumitrascu Anda , Hortopan Dan , Iorgulescu Radu , Poiana Catalina

Background: PBMAH is a rare cause of adrenal Cushing’s syndrome, frequently due to aberrant adrenal expression of hormonal receptors.Aim: To describe 6 patients with PBMAH.Methods: Clinical, hormonal and imagistic evaluation.Results: Age at diagnosis of patients (4M/2F) was 50–79 years. One asymptomatic patient was incidentally diagnosed on abdominal CT, two patients had overt Cushing’s (centra...

ea0037ep915 | Thyroid cancer | ECE2015

Graves' disease and papillary/insular thyroid cancer in a large compressive goitre

Carsote Mara , Dumitrascu Anda , Terzea Dana , Geleriu Andreea , Peretianu Dan , Alexandrescu Daniela , Chirita Corina , Iorgulescu Radu , Goldstein Andrei , Poiana Catalina

Introduction: The association between autoimmune thyroid disease and thyroid cancer is a dynamic field regarding the prevalence data and the common pathogenic background.Aim: We report a sixth decade women case with a 1 year history of Graves’ disease that was discovered with an aggressive differentiated thyroid carcinoma.Case report: M.E. 56-year-old female has a 10 months history of daily medium dose of thyamazolum which was...

ea0070aep94 | Adrenal and Cardiovascular Endocrinology | ECE2020

Results of biochemical testing in suspected primary hyperaldosteronism – a retrospective study

Vladan Andreea , Baranga Iuliana , Dumitrascu Anda , Hortopan Dan , Iorgulescu Radu , Jurcut Ruxandra , Zugravu Adrian , Poiana Catalina , Radian Serban

Background: PA is a frequent cause (5–13%) of secondary hypertension (HT), yet diagnostic work-up of PA remains challenging.Aim: To describe the characteristics of a series of hypertensive patients diagnosed with PA compared to those with negative biochemical screening (aldosterone-to-renin ratio/ARR)Methods: Clinical, hormonal and imaging evaluation.Results: We have screened for PA 34 patients diagnose...

ea0090ep1132 | Late Breaking | ECE2023

Rare phenotype association between pulmonary NET and prolonged hyperkalemia after an unilateral adrenalectomy for primary hyperaldosteronism

Tănasie Denisa-Isabella , Simona Andreea Găloiu , Lavinia Popa Maria , Iordan Ingrid , Constantin Teodor , Iorgulescu Radu , Poiana Catalina

Introduction: We describe the case of a 68-year-old patient, having two MEN1-associated tumors that are not part of the classical triad, with a penetrance of only 40%, and 2%, according to the medical literature. Furthermore, she developed a persistent hyperkalemia after the unilateral adrenalectomy, which is rare and often missed.Case report: In 2011, following a non-specific symptomatology (dry cough, fatigue), a bilobectomy was performed (medium and r...

ea0099ep418 | Adrenal and Cardiovascular Endocrinology | ECE2024

Clinical and hormonal characterisation of 71 patients with bilateral macronodular adrenocortical disease (BMAD)

Vladan Andreea , Baciu Ionela , Baculescu Nicoleta , Burcea Iulia , Capatana Cristina , Dobre Ramona , Dusceac Roxana , Galoiu Simona , Iorgulescu Radu , Niculescu Dan , Trifanescu Raluca , Dumitrascu Anda , Buduluca Larisa , Diculescu Mircea , Radian Serban , Poiana Catalina

Background: BMAD is defined as development of multiple large nodules, >1 cm diameter, with bilateral involvement of the adrenal glands. It is typically associated with endogenous Cushing’s syndrome (CS) and occurs in adults, in the 4th-7th decade of life.Aim: To describe the clinical presentation, the biochemical peculiarities and the management of 71 patients diagnosed with BMAD in a tertiary endocrinology centre.Results:...