Searchable abstracts of presentations at key conferences in endocrinology

ea0038p86 | Clinical practice/governance and case reports | SFEBES2015

Four years of tolvaptan: experience from two large teaching hospitals

Follows Joseph , Iqbal Ahmed , Allahabadia Amit

Introduction: Hyponatraemia is a common cause of morbidity and mortality affecting 15–28% of inpatients. Tolvaptan is a competitive vasopressin 2 antagonist licensed to treat hyponatraemia secondary to the syndrome of inappropriate anti-diuretic hormone secretion (SIADH). There has been concern that tolvaptan treatment may lead to rapid overcorrection of sodium in a minority of patients, thus potentially leading to osmotic demyelination syndrome.Met...

ea0034p62 | Clinical practice/governance and case reports | SFEBES2014

Juvenile granulosa cell tumour of the ovary presenting with hyperprolactinaemic amenorrhoea and galactorrhoea

Iqbal Ahmed , Lubina-Solomon Alexandra , Webster Jonathan

Background: Ovarian granulosa cell tumours are rare, aggressive, hormonally active neoplasms.Case: A 16-year-old, nulliparous, Eastern European woman presented with a 9-month history of secondary amenorrhoea and a 2-month history of galactorrhoea. She denied headache or visual symptoms. Past medical history was unremarkable with menarche at age 14 and a previously normal menstrual cycle. She had never used hormonal contraception. Only medications were pa...

ea0060p01 | (1) | UKINETS2018

Functional or non-function pancreatic NET; Novel use of a flash glucose monitoring system

Arshad Muhammad Fahad , Iqbal Ahmed , Bury Jonathan , Wadsley Jonathan , Munir Alia

High grade pancreatic NETs are usually non-functional. Here, we report a case of a patient with a high grade pancreatic NET, which was initially non-functional but became functional after chemotherapy. He was initiated on a flash glucose monitoring device (FreeStyle Libre®) avoiding the need for frequent capillary blood glucose monitoring. Using this novel approach, we demonstrated an improvement in his disabling hypoglycaemia with medical treatment. A 45-year-old profess...

ea0034p81 | Clinical practice/governance and case reports | SFEBES2014

The patient with broken heart

Solomon Alexandra Lubina , Iqbal Ahmed , Harrison Barney , Webster Jonathan , Bennet William

A 58-year-old gentlemen presented with severe neckache, sweating, feeling hot, and cold. PMH included hypertension and MI. On examination, he was clammy, with blood pressure (BP) 205/107 mmHg. Laboratory results showed leucocytosis 28.5 and TroponinT 2002 ng/l (reference range <14.0). ECG showed inferolateral ST depression. CT angiogram showed a normal aorta and a 6 cm right adrenal mass. An echocardiogram showed severe LV impairment and normal valves.<p class="abstext...

ea0025oc1.8 | Young Endocrinologists prize session | SFEBES2011

TSH levels and thyroid hormone prescribing in primary care in the UK

Iqbal Ahmed , Taylor Peter , Panicker Vijay , Sayers Adrian , Greenwood Rosemary , Mukhtar Rasha , Evans Jonathan , Dayan Colin

Objective: Hypothyroidism is common and predominantly managed in primary care. Symptoms are non-specific, with thyroid function tests (TFT) required for diagnosis. We sought to investigate current practice in levothyroxine prescribing in primary care.Methods: We studied the initiation of levothyroxine using the General Practice Research Database (GPRD), the world’s largest database of anonymised medical records. Individuals with i) thyroid cancer ii...

ea0025p352 | Thyroid | SFEBES2011

Variation in free T3 (fT3) within the reference range is associated with bone development in children, and mediated via alteration in body mass indices

Taylor Peter , Sayers Adrian , Iqbal Ahmed , Taylor Andrew , Dayan Colin , Tobias Jonathan

Objective: The hypothalamus–pituitary–thyroid axis profoundly influences skeletal development. Whilst the adverse effects of thyroid dysfunction on bone are well established; the effects of variation within the normal range is less clear.Design: In a subset of the Avon Longitudinal Study of Parents and Children we performed full thyroid function tests from stored samples taken at age 7. 668 children had thyroid hormone parameters within the ref...

ea0021oc5.8 | Steroids and thyroid | SFEBES2009

The effect of genetic variation in PDE8B and DIO1 on thyroid hormone levels

Taylor Peter , Panicker Vijay , Iqbal Ahmed , Timpson Nicholas , Walsh John , Dayan Colin

Background: Single-nucleotide polymorphisms (SNPs) allow us to study effects of genetic variation on thyroid hormone levels. Phosphodiesterase 8B (PDE8B) is a protein responsible for cAMP generation, found in thyroid and brain tissue, but not normal pituitary tissue. Variation at this locus has been reported to influence TSH levels, but its effect on T3 and T4 had not been studied in the general population. Deiodinase 1 (DIO1) is known to influence T...

ea0073aep833 | Late Breaking | ECE2021

Treatment of severe symptomatic hyponatraemia using hypertonic saline; real world findings from 2017–2020 in two university hospitals in the UK

Fahad Arshad Muhammad , Iqbal Ahmed , Weeks James , Fonseca Ines , Munir Alia , Bennet William

Introduction & aimHypertonic saline (HTS) is an effective treatment for severe symptomatic hyponatraemia. European Society of Endocrinology (ESE) published guidelines to standardise HTS administration in 2014, however, evidence behind the guidelines is limited by virtue of being largely derived from small retrospective studies and expert opinion. The aim of this study was to evaluate the ’real-world’ safety and efficacy of these guidelines....