Searchable abstracts of presentations at key conferences in endocrinology

ea0049gp36 | Bone & Calcium Homeostasis 1 | ECE2017

Relationship between circulating microRNAs and bone mineral density in patients with active acromegaly

Valassi Elena , Garcia-Giralt Natalia , Malouf Jorge , Crespo Iris , Webb Susan M.

Objective: Acromegaly (ACRO) is associated with abnormal bone remodeling and reduced volumetric bone mineral density (vBMD) at the lumbar spine and proximal femur. Circulating microRNAs (miRNAs) modulate the activity of osteoblasts and osteoclasts, and are currently being investigated as potential biomarkers of osteoporosis. The aims of our study were: 1) To identify differentially expressed miRNAs in the serum of five patients with active ACRO vs. healthy controls, and 2) To ...

ea0041ep17 | Adrenal cortex (to include Cushing's) | ECE2016

Psychopathology, memory and quality of life in Cushing’s syndrome

Santos Alicia , Resmini Eugenia , Crespo Iris , Valassi Elena , Martinez Maria Antonia , Pires Patricia , Webb Susan

Introduction: Cushing’s syndrome (CS) has been related to higher psychopathology. Psychopathology can be related to poor memory performance, and low quality of life. The aim of this study is to establish the relationship between the three parameters and with subjective symptom perception in CS.Methods/design: Thirty six patients in remission of CS and 36 matched controls for age, sex and education years were included in the study. They completed SCL...

ea0056p852 | Pituitary - Clinical | ECE2018

Psychopathology in Cushing’s disease and acromegaly

Santos Alicia , Resmini Eugenia , Crespo Iris , Valassi Elena , Martinez Ma Antonia , Webb Susan M

Introduction: Cushing’s disease (CD) and acromegaly, despite their different specific symptoms, often present psychopathology (mainly depression and anxiety) even after hormonal normalization. However, their psychopathological profiles may be different. The aim of this study was to analyse the psychopathological profile in successfully treated Acromegaly and CD, and to compare both diseases. Current hormonal evaluation and time since endocrine control will also be analyse...

ea0037ep64 | Adrenal cortex | ECE2015

Serum brain-derived neurotrophic factor in Cushing's syndrome patients

Santos Alicia , Resmini Eugenia , Barahona Ma Jose , Crespo Iris , Valassi Elena , Martinez Ma Antonia , Marin Ana , Webb Susan M

Introduction: Brain-derived neurotrophic factor (BDNF) is a protein that has been linked to several cardiovascular risk factors and bone status. Stress and corticosteroid exposure can affect BDNF levels, although this has never been studied in Cushing’s syndrome (CS). The aims of this study were to establish if BDNF levels were reduced in CS and to check possible associations to cardiovascular risk factors and bone status.Methods: 52 patients (18 ac...

ea0037ep798 | Pituitary: clinical | ECE2015

Increased serum levels of the Wnt antagonist Dicckopf-1 (DKK1) and impaired trabecular bone mineral density using QCT scan in acromegalic patients

Valassi Elena , Crespo Iris , Aulinas Anna , Urgell Eulalia , Malouf Jorge , Llauger Jaume , Marin Ana Maria , Biagetti Betina , Webb Susan M

Introduction: Acromegaly is associated with increased bone turnover and skeletal fragility. Although the GH/IGF1 system plays an important role in bone homeostasis, effects of GH excess on the Wnt signalling pathway are to be determined. Bone quantitative CT (QCT) provides a volumetric, tridimensional measure of bone mass at the trabecular and cortical level.Aim: i) To compare volumetric bone density (vBMD) using QCT in patients with acromegaly vs gender...

ea0035oc12.5 | Pituitary Basic | ECE2014

Does hypercortisolism of Cushing’s syndrome affect telomere length?

Aulinas Anna , Ramirez Maria Jose , Barahona Maria Jose , Valassi Elena , Resmini Eugenia , Mato Eugenia , Santos Alicia , Crespo Iris , Bell Olga , Surralles Jordi , Webb Susan

Introduction: Hypercortisolism in Cushing’s syndrome (CS) determines increased mortality and morbidity. Hypercortisolism is also present in chronic depressive disorders and stress, where telomere length (TL) is shorter than in controls. We hypothesized that telomere shortening may occur and contribute to premature morbidity in CS.Aim: Investigate TL in CS compared to matched controls, and longitudinally in a subset of CS patients evaluated both with...

ea0032oc4.4 | Adrenal | ECE2013

Neuronal dysfunction in the hippocampi of cured Cushing's syndrome patients, detected by 1H-MR-spectroscopy

Resmini Eugenia , Santos Alicia , Gomez-Anson Beatriz , Lopez-Mourelo Olga , Pires Patricia , Vives-Gilabert Yolanda , Crespo Iris , Portella Maria , de Juan-Delago Manel , Webb Susan

Introduction: Proton magnetic resonance spectroscopy (1H-MRS) is a sensitive, non-invasive imaging technique capable of measuring brain metabolites in vivo. Chronic exposure to endogenous hypercortisolism in Cushing’s syndrome (CS) is associated with negative effects on memory and hippocampal volumes, even after biochemical cure.Objective: To investigate metabolites in the hippocampi of CS patients and controls, using 1</sup...

ea0032p873 | Pituitary – Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2013

Relationship between telomere length and dyslipidemia in patients with Cushing's syndrome

Aulinas Anna , Jose Ramirez Maria , Jose Barahona Maria , Mato Eugenia , Bell Olga , Valiente Cristian , Valassi Elena , Resmini Eugenia , Santos Alicia , Crespo Iris , Corcoy Rosa , Surralles Jordi , Webb Susan M.

Introduction: Cushing’s syndrome (CS) is associated with increased mortality and morbidities. Hypercortisolism is also present in chronic mood disorders (CMD) and stress, where telomere length (TL) has been found to be shorter than in matched controls. Since hypercortisolism is present in CS and CMD, we hypothesized that telomere shortening could also be present in CS. The aim of this study was to investigate TL in CS patients compared to matched controls.<p class="ab...