Searchable abstracts of presentations at key conferences in endocrinology

ea0056p580 | Obesity | ECE2018

Role of IGF1 in regulation of SOD 1 expression and mTOR/S6K signaling in heart of obese male rats

Obradovic Milan , Stanimirovic Julijana , Panic Anastasija , Zafirovic Sonja , Isenovic Esma

Aim: Obesity is associated with activation of mammalian target of rapamycin (mTOR)/ ribosomal S6 kinase (S6K) signaling pathway that promotes cardiac hypertrophy, insulin resistance, endothelial dysfunction and oxidative stress. Although activation of mTOR/S6K has a harmful effect, simultaneously it represents adaptive metabolic response that protects cells from excessive nutrient intake. Insulin like growth factor-1 (IGF1) exerts pleiotropic action on heart promoting vasorela...

ea0016p652 | Signal transduction | ECE2008

Insulin regulation of proliferation involves activation of akt and erk 1/2 signaling pathways in vascular smooth muscle cells

Isenovic Esma , Fretaud Maxenence , Koricanac Goran , Sudar Emina , Velebit Jelena , Dobutovic Branislava , Marche Pierre

This investigation used primary cultured rat vascular smooth muscle cells (VSMCs) to examine the effects of insulin (INS) on proliferation of VSMCs. In this study, protein kinase B (Akt) and p42/44 mitogen-activated protein kinase (ERK 1/2) signaling pathways in mediating the mitogenic actions of INS in VSMCs was investigated. Incubation of a rat VSMCs with INS (100 nM) for 10 min resulted in an increase of Akt phosphorylation by 6-fold (P<0.001) and ERK 1/2 phospho...

ea0073aep294 | Diabetes, Obesity, Metabolism and Nutrition | ECE2021

Serum ferritin levels correlate with ultrasonography-determined liver steatosis severity in type 2 diabetes patients with NAFLD

Mitrovic Bojan , Samardzic Vladimir , Gluvic Zoran , Tomasevic Ratko , Obradovic Milan , Sudar-Milovanovic Emina , Isenovic Esma R.

IntroductionNon-alcoholic fatty liver disease (NAFLD) is a component of metabolic syndrome (MetS). Hence, it is frequently associated with type 2 diabetes mellitus (T2DM). The low-grade inflammation associated with NAFLD usually explained the changes in serum iron metabolism. This study aims to assess the link between liver steatosis severity and serum iron, ferritin, and transferrin levels.Material and methods<p class="abstext...

ea0070aep886 | Thyroid | ECE2020

Ectopic thyroid tissue presented as left adrenal mass – a case report

Samardzic Vladimir , Gluvic Zoran , Lackovic Milena , Tica Jelena , Popovic-Radinovic Vesna , Vujovic Marina , Obradovic Milan , Isenovic Esma R.

Introduction: Ectopic thyroid tissue is a rare developmental abnormality with the prevalence of 1 per 100.000–300.000 persons in the general population. It is most commonly detected in younger women and presented as lingual thyroid. Here we report a rare case of ectopic thyroid tissue in the left adrenal gland.Case report: A 29-year old female without previous medical history was incidentally diagnosed with left adrenal gland mass detected on routi...

ea0022p756 | Thyroid | ECE2010

Have the hypothyroid patients really had ‘euthyroid' quality of life after the euthyroid state is established with levothyroxine-substitution?

Gluvic Zoran , Tica Jelena , Popovic-Radinovic Vesna , Vujovic Marina , Rasic-Milutinovic Zorica , Lackovic Milena , Isenovic Esma , Paunovic Nevena

Introduction: Subclinical and clinical primary hypothyroidism potentially makes a negative influence on the patient’s quality of life. Present study examined the level of hypothyroid symptoms and signs expression as well patient’s quality of life before levothyroxine and after substitutionally-induced laboratory euthyroidism.Material and methods: Prospective case–control study consisted of 75 female patients divided into three groups based...

ea0081ep1030 | Thyroid | ECE2022

Hand and foot skin changes resembling PTU-induced vasculitis in a young male with diffuse toxic goiter- a case report

Tomasovic Martina , Sinik Marija , Joksimovic Bojan , Lackovic Milena , Samardzic Vladimir , Vujovic Marina , Gluvic Zoran , Obradovic Milan , Zafirovic Sonja , Isenovic Esma R.

Propylthiouracil (PTU) sometimes induces autoimmune syndromes, such as PTU–induced lupus or vasculitis. Here we present hands and feet vasculitis-like skin changes observed several days after PTU introduction in a patient who suffered from serious diffuse toxic goiter. Because of segmental distribution, normal liver function test, and no signs of clinical deterioration, it was decided to continue PTU management and observe the patient. Primarily maculopapular rash became ...

ea0063p190 | Diabetes, Obesity and Metabolism 1 | ECE2019

HbA1C as a marker of retrograde glycemic control in diabetes patient with co-existed beta thalassemia: Case report

Gluvic Zoran , Lackovic Milena , Samardzic Vladimir , Jevtic Jelena Tica , Vujovic Marina , Mitrovic Bojan , Vasic-Vlaisavljevic Anita , Taric Marija Popin , Mladenovic Violeta , Radenkovic Sasa , Obradovic Milan , Isenovic Esma R

Introduction: A number of studies reported that almost every fifth patient with thalassemia hav e diabetes. Various factors could contribute to inadequate retrograde glycemic control in thalassemia patients co-existed with diabetes. According to published data, HbA1C seems to be an insufficient marker of the quality of diabetes control in thalassemia patients.Case report: We present a male 67 years old type 2 diabetes patient with disease history for 15 ...

ea0041ep116 | Bone &amp; Osteoporosis | ECE2016

The influence of osteoporosis and cardiometabolic syndrome risk factors on bone mineral density in females with thyroid dysfunction

Gluvic Zoran , Samardzic Vladimir , Lackovic Milena , Tica Jevtic Jelena , Vujovic Marina , Popovic-Radinovic Vesna , Mitrovic Bojan , Popin-Taric Marija , Vasic-Vlaisavljevic Anita , Isenovic Esma R

Introduction: The effects of TSH and thyroid hormones on bone turnover are well-known. The aim of this study is to examine the influence of osteoporosis (Op) and cardiometabolic syndrome risk factors on bone mineral density (BMD) in the population of age-matched, normotensive and nondiabetic females.Material and methods: Cross-sectional study involved 76 females (average age 53±10 years), divided into three groups: hypo-, hyper-, and euthyroid. Pres...

ea0037ep331 | Diabetes (pathiophysiology &amp; epitemiology) | ECE2015

The influence of actual and retroactive T2DM regulation on duration of hospital stay and clinical outcome of patients suffered from NSTEMI/STEMI

Gluvic Zoran , Kovacevic Pejka , Samardzic Vladimir , Jevtic Jelena Tica , Vujovic Marina , Popovic-Radinovic Vesna , Lackovic Milena , Mitrovic Bojan , Tomasevic Ratko , Panic Anastasija , Isenovic Esma R

Introduction: A link between diabetes and coronary heart disease is well-known. The aim of this study is to examine the influence of actual and retroactive diabetes regulation parameters (admission glycaemia and HbA1C value) on duration of hospital stay and clinical outcome of T2DM patients suffered from NSTEMI/STEMI.Material and methods: Cross sectional study involved 103 examinees with past history of T2DM actually hospitalised in CCU due to acute myoc...

ea0070ep390 | Reproductive and Developmental Endocrinology | ECE2020

Quality of life questionnaires in PCOS- the impact of hirsutism

Gluvic Zoran , Lackovic Milena , Samardzic Vladimir , Vujovic Marina , Popovic-Radinovic Vesna , Tica Jelena , Obradovic Milan , Sudar-Milovanovic Emina , Isenovic Esma R.

Introduction: Polycystic ovary syndrome is the most frequent ovarian dysfunction during the reproductive period. Its presence significantly impacts on the final scores of various Quality-of-Life (QoL) questionnaires. This pilot study aims to analyze the impact of hirsutism (H), as the component of PCOS, on the scores of determined generic (General Health Questionnaire-12, GHQ12) and disease-specific questionnaires (Polycystic Ovary Syndrome Questionnaire, PCOSQ) in PCOS subjec...