Searchable abstracts of presentations at key conferences in endocrinology

ea0059p010 | Adrenal and steroids | SFEBES2018

Exploring the utility of renin measurements in the routine management of salt-wasting congenital adrenal hyperplasia

Pofi Riccardo , Cannuccia Amalia , Lenzi Andrea , Isidori Andrea M , Tomlinson Jeremy W

The importance of measuring renin or plasma renin activity (PRA) and aldosterone in establishing mineralocorticoid deficiency is not in doubt. Once mineralocorticoid replacement therapy is initiated, guidance suggests that optimization of mineralocorticoid dose should be based upon measurements of blood pressure, renin (or PRA), and electrolytes. The aim of this study was to explore the relationship between renin and clinically important variables to determine whether measurem...

ea0070aep803 | Reproductive and Developmental Endocrinology | ECE2020

TU score: A new proposal for an ultrasound scoring system to predict testicular function

Carlomagno Francesco , Pozza Carlotta , Gianfrilli Daniele , Tenuta Marta , Sesti Franz , Mazzotta Paola , Lenzi Andrea , Isidori Andrea

Background: Testicular ultrasound (US) is routinely employed in the evaluation of reproductive and sexual function. However, its use for characteristics other than testicular volume is hampered by a lack of information on the prognostic value of its findings, that to date have only been incorporated in a score proposed by Lenz et al. in 1993.Objectives: We sought to explore whether testicular US examination can predict spermatogenesis and provid...

ea0016oc3.5 | Diabetes and obesity | ECE2008

Hormonal regulation of 11-β-HSD1 expression and activity in differentiated 3T3- L1 adipocytes

Pierotti Silvia , Lolli Francesca , Gianfrilli Daniele , Bonifacio Vincenzo , Gandini Loredana , Lenzi Andrea , Isidori Andrea M

Introduction: In humans, testosterone treatment affects body fat distribution and metabolism. The mechanisms involved in these processes are not yet fully understood. We investigated whether sex hormones modulate the expression and activity of type1 11-β-hydroxy-steroid-dehydrogenase (11β-HSD1). 11β-HSD1 catalyses the conversion of inactive cortisone into active cortisol, a key step for the development of functional adipocytes. Based on previous studies an inhib...

ea0075m08 | Metabolic Bone | EYES2021

Safety and efficacy of PTH 1-34 and 1-84 therapy in chronic hypoparathyroidism: a meta-analysis of prospective trials

Hasenmajer Valeria , Puliani Giulia , Sada Valentina , Tarantino Chiara , Lenzi Andrea , Isidori Andrea

Introduction: Hypoparathyroidism is the only endocrine deficiency for which replacement therapy with the missing hormone is not part of the clinical practice. High quality evidence on the use of PTH 1-34 or PTH 1-84 in hypoparathyroidism is missing.Objective: We aim to evaluate the efficacy and safety of PTH 1-34 and PTH 1-84, and to compare the two treatments when possible.Methods: We searched databases up to March 2021 for random...

ea0049ep1050 | Pituitary - Clinical | ECE2017

Effects of somatostatin analogs on glucose metabolism in acromegalic patients: a meta-analysis of prospective interventional studies

Feola Tiziana , Cozzolino Alessia , Simonelli Ilaria , Sbardella Emilia , Puliani Giulia , Giannetta Elisa , Pasqualetti Patrizio , Lenzi Andrea , Isidori Andrea M

Introduction: Glucose metabolism impairment is a common complication of acromegaly. Somatostatin analogs (SSAs) are used as both first and second line treatment. The effect of SSAs on glucose metabolism in acromegaly is still debated.Aim: To address the following questions: 1) do SSAs affect glucose metabolism? 2) does the effect correlate with disease control? 3) do different SSAs – Lanreotide (LAN) and octreotide LAR (OCT) – affect metabolism...

ea0049ep1054 | Pituitary - Clinical | ECE2017

Quantitative analysis of the pituitary gland at magnetic resonance imaging in obese patients

Puliani Giulia , Lubrano Carla , Fiorelli Marco , Sbardella Emilia , Graziadio Chiara , Gianfrilli Daniele , Lenzi Andrea , Isidori Andrea M

Background: Hypothalamic-pituitary function and adipose tissue are deeply interconnected. Obesity has been linked to morpho-functional changes in several endocrine glands (thyroid, adrenal, gonads). No study has quantified the appearance of the pituitary gland in obese subjects.Aim: To measure pituitary signal intensity, homogeneity and texture of the pituitary gland at magnetic resonance (MR) in obese subjects free of focal pituitary disease.<p clas...

ea0070aep528 | Endocrine-related Cancer | ECE2020

Sarcopenia can predict response to therapy in NSCLC patients treated with PD-1 inhibitors: A longitudinal prospective study.

Tenuta Marta , Sbardella Emilia , Pandozzi Carla , Gelibter Alain J. , Sirgiovanni Grazia , Giannetta Elisa , Pozza Carlotta , Lenzi Andrea , Isidori Andrea

Introduction: Immune checkpoint inhibitors (ICI) show promising efficacy in the treatment of a wide range of advanced cancers, butlong-term response is currently limited to a subset of patients. Sarcopenia is a condition characterized by loss of skeletal muscle mass and decreased muscle function which occurs in approximately 50% of advanced cancer patients,related to malnutrition, inflammation, and treatments.Objective: The aim of this prospective o...

ea0075a10 | Adrenal gland | EYES2021

Impact of adrenalectomy on cardiovascular features in patients with adrenal incidentalomas and possible autonomous cortisol secretion: Results from ITACA study

Minnetti Marianna , Bonaventura Ilaria , Angelini Francesco , Sbardella Emilia , Pofi Riccardo , Cozzolino Alessia , Gianfrilli Daniele , Lenzi Andrea , Isidori Andrea M.

Background: Patients with adrenal incidentalomas and possible autonomous cortisol secretion (pACS) suffer from a high rate of cardiovascular events and mortality. We have previously showed that left ventricular mass index (LVMi) is higher in patients with pACS, compared with patients with non-functioning adenomas (NFA). To date, the management of pACS is still controversial, with a lack of consensus regarding the benefits of surgery.Objectives: This pros...

ea0081p280 | Adrenal and Cardiovascular Endocrinology | ECE2022

Coagulation parameters in asymptomatic patients with adrenal incidentaloma: is mild autonomous cortisol secretion correlated with thromboembolic risk?

Minnetti Marianna , Bonaventura Ilaria , Hasenmajer Valeria , De Alcubierre Dario , Tomaselli Alessandra , Ferrari Davide , Pofi Riccardo , Cozzolino Alessia , Sbardella Emilia , Lenzi Andrea , Isidori Andrea

Background: Overt hypercortisolism is highly associated with venous thromboembolism. Patients with Cushing’s syndrome (CS) typically show an alteration of the intrinsic coagulation pathway, especially an increase in factor VIII (f-VIII), and increased levels of coagulation inhibitors (i.e., antithrombin III) as a compensatory response. Mild autonomous cortisol secretion (MACS) has been variably associated with higher risk of cardiovascular events and mortality compared to...

ea0081p390 | Endocrine-Related Cancer | ECE2022

Uncovering the immune profile in well-differentiated gastroenteropancreatic neuroendocrine tumors

Sesti Franz , Puliani Giulia , Sciarra Francesca , Feola Tiziana , Centello Roberta , Di Vito Valentina , Pandozzi Carla , Lenzi Andrea , Isidori Andrea , Venneri Mary Anna , Faggiano Antongiulio , Giannetta Elisa

Introduction: Immune tumor microenvironment plays a key role in tumors’ growth and metastatic spread, while its role in the heterogeneous field of neuroendocrine neoplasms (NENs) remains unclear. There is evidence that tumor progression in NENs is promoted by an immunosuppressed microenvironment created by a plethora of infiltrating immune cells. Changes in circulating leukocyte and peripheral blood mononuclear cell (PBMC) subpopulations can mirror the local alteration of...