Searchable abstracts of presentations at key conferences in endocrinology

ea0016p543 | Obesity | ECE2008

Glucose-dependent insulinotropic polypeptide (GIP) modulates inflammatory markers and regulates cell proliferation in subcutaneous adipose tissue

Gogebakan Ozlem , Mosig Sandy , Middelbeck Ines , Osterhoff Martin A , Isken Frank , Rudovich Natalia , Pfeiffer Andreas F H

Background: Glucose-dependent insulinotropic polypeptide (GIP) is a gastrointestinal hormone that is secreted in response to food intake and modulates β-cell function. Remarkably, GIP looses its insulinomimetic effect in the presence of chronic hyperglycaemia and thus appears to be ineffective in poorly controlled T2DM at least with regard to insulin release. The mechanism by which this occurs is not clear and it is not known.Objectives: To analyse ...

ea0016p515 | Obesity | ECE2008

Glucose-dependent insulinotropic polypeptide (GIP) receptor knock-out prevents ovariectomy-induced obesity in mice

Isken Frank , Pfeiffer Andreas FH , Nogueiras Ruben , Osterhoff Martin A , Ristow Michael , Thorens Bernard , Tschop Matthias H , Weickert Martin O

Objectives: Premature estrogen deficiency and menopause are associated with increases in body weight and fat mass. Ovariectomized (OVX) mice also show reduced locomotor activity. Because glucose-dependent-insulinotropic-polypeptide (GIP) is known to play an important role both in fat metabolism and locomotor activity, we hypothesized that effects of estrogen on the regulation of body weight, fat mass and spontaneous physical activity could be mediated in part by GIP signaling....