Endocrine Abstracts

Introduction: The EMPA-REG OUTCOME is a cardiovascular safety study with empaglifozin that has shown a reduction in cardiovascular mortality and a decrease in hospitalization for heart failure. Our work is based on the analysis of the protocol that recognized five changes, the last, 3 years after the start of the study and which affects the definitions of the elements of the primary composite, and following these modifications, we find that the mortality Cardiovascular was inc...

IAS is common in Japanese but rare in Caucasians. Highlighting its aetiology is paramount in understanding its clinical and analytical variabilities and can help planning investigations and avoid mistakes in the interpretation of false pancreatic endocrine data commonly associated with this syndrome.The underlying aetiology of IAS is the presence of high affinity/avidity endogenous insulin autoantibodies in significant amounts in non-diabetics. Clinicall...

Congenital Adrenal Hyperplasia is a group of autosomal recessive disorders characterised by enzyme defects in the steroidogenic pathways involved in the biosynthesis of cortisol, aldosterone and androgens. 21-hydroxylase deficiency accounts for more than 90% of cases.Case history: 41-yr-old female was referred to Endocrinology with a serum testosterone of 14.3 nmol/l (0.20–2.86). She was a full term baby born to non...

40years old lady with 12 months history of hyperthyroidism. Treated with ATD. Referred by her treating physician for RAI therapy due to intolerance to ATD and high dose requirement after 12 months. Patient being treated as Classical Graves’ Hyperthyroidism. She had symptoms of hyperthyroidism at time of presentation but none at time of assessment in our hospital. Main current issue was painful neck swelling: developed slowly over preceding two months. No problems with swa...

In this report, we described pulmonary hypertension (PH) in two patients with growth hormone insensitivity (GHI) who are taking IGF-I(increlex) for along time.Case 1: 6-year-old male patient who has been followed for 4 years with the diagnosis of GHI. He was admitted to the hospital with the complaints of hypoglycemia and severe short stature (height SDS: −7.4). His physical examination, laboratory findings(GH>40 μg/dl, IGF-IA homozygous m...

A 39 years old lady who started to develop hypoglycemia three month following gastric bypass surgery. She is known to have Type 2 DM, dyslipidemia hypertension and Hirsutism. Her weight on presentation was 93.5 kg (pre operation was 104 kg) and Ha1c was 6% (pre operation was 10.5%). She was off diabetes medications. Hypoglycemia mainly fasting some readings < 3 mmol/l, with symptoms (diaphoresis, fatigue and weakness) but sometime hypoglycemia occur 2–3 h post prandia...

Chronic kidney disease (CKD), with or without dialysis, often prompt biochemical tests for pheochromocytoma diagnosis due to high blood pressure, hemodynamic instability or association with certain genetic syndromes. Our objective was to assess plasma free metanephrine and normetanephrine in CKD disease patients, with or without dialysis.Methods: Plasma free metanephrine and normetanephrine were measured by an enzyme-linked immunosorbent assay in 42 pati...

Introduction: Generously supported by IPSEN)-->Insulin tolerance test (ITT) is considered as the gold standard assessment for hypothalamic–pituitary–adrenal axis (HPA) integrity. Short synacthen test (SST) is a relatively simple, low-cost and well tolerated first line test of HPA despite concerns regarding accuracy. The glucagon stimulation test (GST) is often used as an alternative to the ITT. Although less reliable, it is...

Diabetic nephropathy, the leading cause of end-stage renal disease, is characterized by a pro-apoptotic and pro-oxidative environment. The mechanisms by which lifestyle interventions, such as exercise, benefits diabetic nephropathy are unknown. We hypothesized that exercise inhibits early diabetic nephropathy via attenuation of the mitochondrial apoptotic pathway and oxidative damage. Type 2 diabetic db/db and normoglycemic wild type mice were exercised for an hour ever...

We present a case of a 56-year-old male who reported to us with history of instability of gait since one year which was acute in onset and progressive, there was also history of hearing impairment and constipation since 3 years without improvement despite several symptomatic treatments. There was no history of weakness in any part of body, headache, vomiting, convulsions or alteration of sensorium. There was no history of trauma to the head, fever or drug intake. On examinatio...