Endocrine Abstracts

Pancreatic islet beta cells contain a substantial amount of chelatable zinc (Zn2+), where it acts as a structural component of insulin packaging and is also co-secreted with insulin. Zinc at concentrations found in the pancreas is potentially harmful, and like in the brain, its permeation into endocrine cells may trigger the destruction of the islet leading to the onset of diabetes. Despite the potential importance little is known about the permeation pathways of zi...

Background: Pituitary adenomas are monoclonal neoplasms that may be either functional (hormone-secreting) or non-functional. The processes associated with pituitary tumor development and progression are mostly unknown. Remodeling of the extracellular matrix (ECM) and cell adhesion were suggested to be involved in pituitary tumorigenesis. Heparanase, an endoglycosidase capable of degrading heparan sulfate, the main polysaccharide constituent of the ECM, is implicated in diverse...

Context: The prevalence of NCAH among Turkish women with hirsutism has not been established so far.Objective: To evaluate the prevalences of 21-hydroxylase (21-OHD) and 11-β hydroxylase deficiencies by ACTH stimulation test among hirsute women.Patients and methods: The study population consisted of 285 premenopousal women, aged 16–46 years (mean: 23.2±0.3). All were hirsute and hyperandrogenic. Androgen secreting tum...

Introduction: Obesity and its comorbidities, specially type 2 diabetes (T2D), are a major public health problem. The disappointing result of dietary treatment and the scarce of drugs have led to increased bariatric surgery (BS) as the most efficient therapeutic option. However, not all obese patients with T2D who undergo BS achieve diabetes remission.Objective: To develop a genetic scoring system for predicting T2D remission following BS. 2) To compare o...

Fat accumulation, lipogenesis and glycolysis are key contributors to hepatocyte metabolic reprogramming and the pathogenesis of non-alcoholic liver fatty liver disease (NAFLD). The molecular mechanisms affected by steatosis and inflammation in the obese state remain unknown. Here we report that obesity leads to dysregulated expression of protein-tyrosine phosphatases in human livers. Protein Tyrosine Phosphatase Receptor Kappa (PTPRK) levels were increased in hepatocytes by st...