Searchable abstracts of presentations at key conferences in endocrinology

ea0014p116 | (1) | ECE2007

Conjugated and unconjugated serum steroid hormone concentrations in relation to tumour receptor status in postmenopausal breast cancer patients

Vincze Borbála , Pommersheim Ferenc , Udvarhelyi Nora , Horváth Zsolt , Kapuvári Bence , Boldizsár Mariann , Köves István , Orosz Zsolt , Láng István

Human breast cancer tissue is able to concentrate estrogens. 17-beta-estradiol (E2) and estrone (E1) are produced locally through several mechanisms, e.g. from conjugated and unconjugated steroid hormones uptaken from the circulation. This study was aimed to investigate the correlation between endogenous serum sex steroid concentrations and tumour receptor status in postmenopausal breast cancer patients undergoing surgical intervention. The study involved 740 postmenopausal pa...

ea0014p141 | (1) | ECE2007

Thyroglobulin-antibodies in the “normal” range may decrease the diagnostic accuracy of thyroglobulin in the care of patients with differentiated thyroid cancer

Zoltán Locsei , Erzsébet Toldy , István Szabolcs , Gábor Kovács L.

Issue: The use of thyroglobulin (Tg) as tumor marker in differentiated thyroid cancer (DTC) is limited in the presence of thyroglobulin-antibodies (TgAb) but it is generally believed that this is true only for TgAb concentrations over the normal ‘cut off’ point.The aim: Of this study was to investigate if TgAb-s in the normal range, considered to be physiological, may also influence the accuracy and clinical relevance of Tg measurement.<p c...

ea0014p570 | (1) | ECE2007

The role of vasopressin in the hypothalamo-pituitary-adrenal axis regulation during the perinatal period: paradoxical corticosterone elevation without an ACTH rise

Zelena Dóra , Barna István , Mergl Zsuzsa , Domokos Ágnes , Csabai Katalin , Makara Gábor B

Early life events have special importance in the development and may affect the lifetime vulnerability to diseases. For correct interpretation of the long-term consequences it is crucial to understand the immediate effects. The role of vasopressin in hypothalamo-pituitary-adrenal axis regulation as well as in stress-related affective disorders is important therefore we addressed the question if the lack of this hormone will modify the perinatal stress reactivity.<p class="...

ea0014p100 | (1) | ECE2007

Inhibition of C17,20-lyase activity by new 17β-exo-heterocyclic androsterone derivatives

Szécsi Mihály , Tóth István , Wölfling János , Schneider Gyula , Julesz János

17α-Hydroxylase-C17,20-lyase (P45017α) is a key regulator enzyme of the steroid hormone biosynthesis in both the adrenals and the testes. Inhibition of this enzyme can block androgen synthesis in an early step, and may thereby be useful in the treatment of prostatic carcinoma, which is androgen-dependent in the majority of cases. Abiraterone and its analogues have been found strong inhibitors of P45017α suggesting that steroid de...

ea0014p162 | (1) | ECE2007

Segregation of P25L and S80I mutations of the vhl gene in an extended Hungarian family with von Hippel-Lindau syndrome

Patócs Attila , Balogh Katalin , Tóth Miklós , Fazakas Ferenc , Likó István , Rácz Károly

Background: von Hippel-Lindau syndrome (VHL) is a rare autosomal dominant disease caused by alterations of the vhl tumor-suppressor gene. Patients with VHL are at risk for development of retinal, central nervous system and spine hemangioblastomas, clear-cell renal cell carcinomas, pheochromocytomas, endolymphatic sac tumors and cysts; and pancreatic islet cell tumors. Based on the presence or absence of pheochromocytoma as a phenotypic marker, VHL can be divided into di...

ea0014p315 | (1) | ECE2007

Significance of accurate serum thyroglobulin cut-off values in the postoperative follow-up of differentiated thyroid carcinoma

Boér András , Vincze Borbála , Sinkovics István , Keresztes Sándor , Kapuvári Bence , Boldizsár Mariann , Remenár Éva , Otto Szabolcs

The present study was undertaken to evaluate the diagnostic performance of a high-sensitive thyroglobulin (Tg) immunoradiometric assay (BRAHMS Tg-S) in the follow-up of papillary and follicular thyroid cancer patients treated with total/nearly total thyreoidectomy and radioiodine ablation therapy. During TSH suppression serum Tg concentration was measured 6 weeks prior to the radioiodine ablation (onT4-Tg before ablation) as well as 3 months following treatment (onT4–Tg a...

ea0014p557 | (1) | ECE2007

Comparative analysis of reactivity of macroprolactin in first and second-generation prolactin assays

Rigó Erzsébet , Toldy Erzsébet , Löcsei Zoltán , Toldy Erzsébet , Szabolcs István , Kovács Gábor L.

Issue: Macroprolactin (MPRL) is a high molecular mass complex of prolactin with minimal bioactivity in vivo that may be the cause of elevated serum prolactin (PRL) as determined by immunoassay. Unrecognised macroprolactinemia can lead to misdiagnosis and mistreatment. The frequency of MPRL is highly dependent on the affinity of the antibody used in the assay.The aim of this study: Was to compare the frequency and quantity of MPRL measured by a first and ...