Endocrine Abstracts

AimTo assess the relative expression of tissue inhibitor of metalloproteinase-1 gene (TIMP1) and chitinase-3-like protein 1 gene (CHI3L1) in fine-needle aspiration biopsy (FNAB) washouts and the serum levels of their protein products (TIMP-1 and chitinase-3-like protein 1 also known as YKL-40) in patients with histologically confirmed papillary thyroid cancer (PTC) and with benign nodules. Further, we evaluated the correlation between the gene expression...

Objectives: To evaluate the quality of life (QoL) in patients with differentiated thyroid cancer (DTC) by a validated thyroid-specific questionnaire and to identify factors with significant impact on the QoL.Methods: Two hundred DTC patients, treated in one tertiary center, were recruited in the study. One year after the thyroid surgery, they completed the QoL Cancer Survivor Instrument – Thyroid version questionnaire. The questionnaire assessed the...

PTH increases calcium uptake from bone, tubular calcium reabsorption and renal phosphate excretion, and by stimulating 1α-OH vitamin D hydroxylase in the kidney increases production of 1,25(OH)2D.Aim: To differentiate and characterize the various diseases associated with an increase in PTH in the material of the Endocrinology Clinic, Sofiamed University Hospital for 3 years.Material: 167 patients with elevated PTH were examine...

Background: Retinol-binding protein 4 (RBP4) is known as an acute phase inflammatory reactant, associated with insulin resistance. Increased levels of this novel adipokine is observed in obesity, type 2 diabetes mellitus, metabolic syndrome (MetS) and cardiovascular diseases, as well as in nonalcoholic fatty liver disease (NAFLD), but some of these data remain controversial. The aim of this study was to evaluate the relationship between RBP4 and prediabetes in...