Searchable abstracts of presentations at key conferences in endocrinology

ea0094p60 | Metabolism, Obesity and Diabetes | SFEBES2023

Predictors of weight loss in a secondary care tier 3 specialist weight management service

Adapa Shashank , Hameed Saira , Izzi-Engbeaya Chioma

Background: A four-tiered system is currently in place for weight management in the National Health Service (NHS). Tier 3 comprises specialist weight management services and aims for a clinically meaningful weight loss of ≥5%, as recommended by the National Institute for Health and Care Excellence (NICE). Within the Imperial Weight Centre (IWC), patients receive support from a multi-disciplinary team including endocrinologists, surgeons, dietitians, nurs...

ea0065p283 | Neuroendocrinology | SFEBES2019

Review of acromegaly management and outcomes in Imperial College Healthcare NHS Trust over eleven years

Nuttall Ciara , Izzi-Engbeaya Chioma , Mendoza Nigel , Nair Ramesh , Abbara Ali , Martin Niamh , Hatfield Emma

Background: Acromegaly is associated with multiple co-morbidities and increased mortality. Surgery is the first-line intervention and remission of acromegaly can restore normal life-expectancy. Pre-operative somatostatin analogues (SSA) may increase the likelihood of remission in large invasive tumours by causing tumour shrinkage prior to surgery.Aims: To audit the management of acromegaly patients at Imperial College Healthcare NHS Trust (ICHNT) against...

ea0031p91 | Clinical practice/governance and case reports | SFEBES2013

A painful neck in a young well looking man presenting to A&E

Izzi-Engbeaya Chioma , Zac-Varghese Sagen , Palazzo Fausto , Meeran Karim , Dhillo Waljit S

A 38-year-old man presented on the acute medical take with a week’s history of sore throat, dysphagia, neck swelling, and fever. One month prior he had suffered a respiratory tract infection, which resolved without antibiotics. He had no notable past medical and family history. He was a non-smoker and drank 15 units of alcohol per week. On examination he looked well, was afebrile, sweaty and flushed; chest was clear, heart sounds were normal, regular pulse (110 bpm) and B...

ea0077p58 | Metabolism, Obesity and Diabetes | SFEBES2021

Outcomes of postmenopausal women with non-alcoholic fatty liver disease (NAFLD)

Izzi-Engbeaya Chioma , Forlano Roberta , Mullish Benjamin H , Tan Tricia M , Yee Michael , Manousou Pinelopi , Dhillo Tricia S

Background: Non-alcoholic fatty liver disease (NAFLD), encompasses hepatic steatosis alone (NAFL), steatohepatitis (NASH), NAFL/NASH with fibrosis and cirrhosis. Severe fibrosis and cirrhosis are associated with increased risk of morbidity and mortality (due to cardiovascular events, end-stage liver failure and cancer). Postmenopausal women are a high-risk group of patients that have worse outcomes, but the specific factors that place them at higher risk are incompletely under...

ea0077p82 | Neuroendocrinology and Pituitary | SFEBES2021

Pituitary and gonadal axes in patients with ‘Long COVID’: post hoc analysis

Clarke Sophie , Phylactou Maria , Patel Bijal , Mills Edouard , Muzi Beatrice , Izzi-Engbeaya Chioma , Choudhury Sirazum , Khoo Bernard , Meeran Karim , Comninos Alexander , Abbara Ali , Tan Tricia , Dhillo Waljit

Background: It is apparent that COVID-19 may cause persistent symptoms beyond 12 weeks (‘long COVID’). However its underlying pathophysiology is unclear. Several symptoms of long COVID draw similarities to that of endocrine diagnoses. We recently observed that adrenal and thyroid function were normal in survivors of COVID-19 at follow-up. Here we assess additional endocrine axes that could plausibly have a role in long COVID to determine their relationship to ongoing...

ea0086p117 | Reproductive Endocrinology | SFEBES2022

Quantifying the Variability in the Outpatient Assessment of Reproductive Hormone levels

Adams Sophie , Voliotis Margaritis , Phylactou Maria , Izzi-Engbeaya Chioma , Mills Edouard , Thurston Layla , Hanassab Simon , Tsaneva-Atanasova Krasimira , Heinis Thomas , Comninos Alexander , Abbara Ali , Dhillo Waljit

Background: Due to practical limitations, the diagnosis of hypogonadism is predominantly based on a single measure of reproductive hormones, often with confirmation on a second occasion. Factors associated with reproductive hormone variation include: pulsatile secretion, diurnal rhythm, and food intake, which can affect the accuracy of diagnosis of reproductive disorders. There is limited data quantitatively estimating the variability of reproductive hormone levels over the da...

ea0090rc10.2 | Rapid Communications 10: Diabetes, Obesity, Metabolism and Nutrition 2 | ECE2023

Increased risk of cirrhosis in post-menopausal women with NAFLD

Izzi-Engbeaya Chioma , Eng Pei , Dunin-Borkowska Aleksandra , Forlano Roberta , Mullish Benjamin H , Sigon Giordano , Lin Vicky , Tan Tricia , Yee Michael , Manousou Pinelopi , Dhillo Waljit

Background: Non-alcoholic liver disease (NAFLD) affects up to 30% of adults worldwide. With the prevalence of NAFLD increasing after menopause, women aged >55 years are more likely to progress to advanced fibrosis than men. Moreover, liver decompensation secondary to NAFLD is more frequent in women compared to men. However, the causes of these differential outcomes are not fully understood.Methodology: We performed a retrospective cohort study utilis...

ea0069oc9 | Oral Communications | SFENCC2020

Should SHBG be measured in every patient before diagnosing hypogonadotrophic hypogonadism?

Phylactou Maria , Abbara Ali , Eng Pei Chia , Clarke Sophie , Izzi-Engbeaya Chioma , Jayasena Channa , Comninos Alexander , Howard Sasha , Tan Tricia , Dhillo Waljit

Section 1: Case history: A 19-year-old British-Asian man presented with a two-year history of gynaecomastia. He had no other symptoms of hypogonadism. He had an unremarkable past medical history, did not take any regular medications and denied the use of any illicit drugs. There was a family history of consanguinity, with his parents being first cousins. On examination, his BMI was 28 kg/m2 and he had post-pubertal-sized testes (20 ml) with normal secondary sexual c...

ea0065p313 | Neuroendocrinology | SFEBES2019

Prolactinoma causing visual disturbance in pregnancy – a multidisciplinary management conundrum

Azam Sultana , Scott Rebecca , Izzi-Engbeaya Chioma , Jarvis Sheba , Samarasinghe Suhaniya , Comninos Alexander , Hill Neil , Ali Mahamoud Hassan , Nair Ramesh , Hatfield Emma , Martin Niamh , Martin Karim

A 33 year old primip presented to the local ophthalmic hospital at 34+4 weeks’ gestation with two weeks of blurred vision. Examination revealed a bitemporal hemianopia and reduced visual acuity. She was previously fit and well, and a pre-eclampsia screen was negative. An MRI scan demonstrated a haemorrhagic pituitary lesion extending into the suprasellar cistern with mild compression of the optic chiasm. Pituitary function tests showed a raised prolactin 3844 mU/l, isolat...

ea0065p373 | Reproductive Endocrinology and Biology | SFEBES2019

Should SHBG be measured in every patient before diagnosing hypogonadotrophic hypogonadism?

Phylactou Maria , Abbara Ali , Eng Pei Chia , Clarke Sophie A. , Papadopoulou Deborah , Izzi-Engbeaya Chioma , Jayasena Channa N , Comninos Alexander N , Tan Tricia , Dhillo Waljit S

Case: A 19-year-old British-Asian man presented with a two-year history of gynaecomastia. He had no other symptoms of hypogonadism. On examination, BMI was 28 kg/m2 and he had post-pubertal-sized testes (20 ml) with normal secondary sexual characteristics. Hypogonadism was confirmed by two morning fasting total testosterone levels of 4.7 and 5.2 (RR 9.2–31.6 nmol/l). Haemoglobin was normal (152 g/l) and serum oestradiol was <100 pmol/l. He had inappropriate...