ea0005s23 | The Adipocyte as an Endocrine Organ | BES2003
Morton N
, Paterson J
, Masuzaki H
, Holmes M
, Staels B
, Fievet C
, Walker B
, Flier J
, Mullins J
, Seckl J
Metabolic Syndrome (visceral obesity, insulin resistance, type2 diabetes) resembles Cushing's syndrome, but lacks elevated circulating cortisol levels. This has engendered the hypothesis that excessive local glucocorticoid regeneration, resulting from elevated adipose 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD-1) underlies the Metabolic Syndrome. We report that 11beta-HSD-1 nullizygosity (11beta-HSD-1-/-) reduced intra-adipose corticosterone levels and i...