Searchable abstracts of presentations at key conferences in endocrinology

ea0008p17 | Cytokines and growth factors | SFE2004


Muller M , Sales KJ , Katz A , Jabbour HN

Previous studies have demonstrated over-expression of cyclooxygenase-2 (COX-2) enzyme and enhanced synthesis of prostanoids, such as prostaglandin E2 (PGE2), in cervical carcinomas. PGE2 mediates its is effects by interacting with one of four receptors termed EP1-4. Expression and signalling of EP receptors, including EP4, are elevated in cervical carcinomas. We have previously proposed that in addition to endogenous PGE2, EP recepto...

ea0008oc15 | Neuroendocrinology and Reproduction | SFE2004

PGF2alpha -FP receptor signalling is a potential regulator of endometrial vascular function

Sales KJ , Williams ARW , Anderson RA , Naor Z , Jabbour HN

Prostaglandin F2a (PGF) receptor (FP) expression is up-regulated in neoplastic epithelial and perivascular cells in endometrial adenocarcinomas, indicating potential regulation of vascular function by PGF via the FP receptor. This study investigated the potential role of PGF-FP receptor signalling in modulating vascular function in endometrial adenocarcinomas.Endometrial biopsies were obtained in accordance with Ethics Committee guidance with ...

ea0008p47 | Endocrine Tumours and Neoplasia | SFE2004

Elevated FP receptor signalling in endometrial adenocarcinoma cells promotes expression of inflammatory and angiogenic genes via the EGFR and ERK1/2 pathways

List T , Boddy SC , Sales KJ , Jabbour HN

Prostaglandin F2a (PGF) is biosynthesised by cyclooxygenase (COX) enzymes and mediates its activity following FP receptor activation. Recently, we have shown elevated FP receptor expression and signalling in endometrial adenocarcinomas. This study investigated FP receptor signalling in human endometrial adenocarcinoma (Ishikawa) cells.Ishikawa cells were stably transfected with FP receptor cDNA in the sense (FPS) and antisense (FPAS) orientati...