Searchable abstracts of presentations at key conferences in endocrinology

ea0099ep924 | Pituitary and Neuroendocrinology | ECE2024

Experiences with pasireotide treatment in subjects with acromegaly

Kužma Martin , Vanuga Peter , Jackuliak Peter , Payer Juraj

Currently, acromegaly is treatable by 3 groups of drugs available for the treatment of acromegaly: dopamine agonists (DA), somatostatin analogues (SRL) and a growth hormone receptor blocker (GH receptor antagonist GHRA). More recently, pasireotide and pasireotide-LAR were developed as multi-receptor targeted SRLs with higher potency than 1st generation SRLs/octreotide-LAR and lanreotide/and until now were considered second generation SRLs. Pasireotide, unlike first-generation ...

ea0032p249 | Clinical case reports – Pituitary/Adrenal | ECE2013

Extraadrenal paraganglioma: case report

Payer Juraj , Teliarova Zuzana , Jackuliak Peter , Kollerova Jana , Breza Jan

The presence of pheochromocytoma/paraganglioma can be characterized by typical clinical signs, due to hemodynamic and metabolic activity of circulating catecholamines or less a consequence of other amines or neuropeptides produced simultaneously. But the clinical picture can be also very different and can play a clinical picture of other diseases.The authors present a case report from a patient with retroperitoneal paraganglioma. The patient was admitted...

ea0090p633 | Diabetes, Obesity, Metabolism and Nutrition | ECE2023

The prevalence of vitamin D deficiency in hospitalized patients with COVID-19 decreased significantly during the pandemic in Slovakia between the years 2020-2022

Smaha Juraj , Jackuliak Peter , Kužma Martin , Max Filip , Binkley Neil , Payer Juraj

Background: The coronavirus disease 2019 (COVID-19) pandemic led to changes in lifestyle, which could influence vitamin D status on a population level. The purpose of our study was to compare 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalized because of severe COVID-19 during two waves of the pandemic (2020/21 vs. 2021/22).Materials and methods: We analyzed 101 patients (61 males/ 40 females) hospitalized in the internal medicine department of...

ea0035p22 | Adrenal cortex | ECE2014

Hyponatremia as a predictor of in-hospital mortality

Sturdik Igor , Adamcova Monika , Kollerova Jana , Koller Tomas , Zelinkova Zuzana , Jackuliak Peter , Payer Juraj

Background: Hyponatremia is the most common electrolyte abnormality, it increases morbidity and mortality, but it is not clear if this condition influences mortality independently of other contributing factors. The aim of our study was to assess the relative contribution of hyponatremia to in-hospital mortality and to determine predictive factors associated with hyponatremia-related mortality.Materials and methods: A database search was conducted for all...

ea0035p676 | Growth hormone IGF axis basic | ECE2014

GH replacement therapy affects the morphology and function of the left ventricle in patients with adult-onset GH deficiency

Dlesk Anton , Kamensky Gabriel , Lazurova Ivica , Kuzma Martin , Jackuliak Peter , Payer Juraj

Background: GH plays an important role in maintaining physiological morphology and function of the left ventricle (LV). In GH deficient (GHD) patients a systolic and/or diastolic LV dysfunction has been documented. LV systolic dysfunction results from reduced LV mass (LVM), which subsequently leads to a decrease of the LV ejection fraction (EF). Results from clinical trials evaluating the effect of GH replacement therapy on the morphological and functional changes of the LV in...

ea0022p98 | Bone/Calcium | ECE2010

Teriparatide in the treatment of severe osteoporosis: results of a multicenter prospective study

Payer Juraj , Tomkova Sona , Killinger Zdenko , Jackuliak Peter , Vanuga Peter , Letkovska Alexandra , Masaryk Pavol , Kmecova Zlata

Introduction: Teriparatide (TPTD) is a recombinant aminoterminal fragment (1–34) of the human parathyroid hormone (PTH), which has a predominantly stimulating effect on bone formation. We report results of an 18-month prospective multicenter study with daily s.c. application of 20 μg of teriparatide in 85 elderly women with severe osteoporosis, the efficacy, safety and compliance of the treatment.Outcomes: The primary outcomes were defined as c...

ea0070aep170 | Bone and Calcium | ECE2020

Long term effect on trabecular bone score but not BMD is preserved in GH-deficient adults only when sufficient vitamin D levels are maintained

Kužma Martin , Smaha Juraj , Stojkovičová Daša , Jackuliak Peter , Killinger Zdenko , Payer Juraj

Introduction: Adult growth hormone deficiency (AGHD) is associated with lower bone mass and likely with increased risk of fragility fractures. GH replacement leads to increase in bone mineral density (BMD) and trabecular bone score (TBS). The effect of adequate levels of vitamin D during GH replacement is important to provide effect on TBS.Aim: To assess long–term effectof recombinant GH replacement on BMD and TBS with regards to vitamin D levels d...

ea0056p175 | Bone ' Osteoporosis | ECE2018

Acromegaly patients with vertebral fractures, have lower trabecular bone score despite no difference in bone mineral density, than non-fractured patients and healthy controls

Kuzma Martin , Vanuga Peter , Sagova Ivana , Pavai Dusan , Jackuliak Peter , Killinger Zdenko , Binkley Neil , Genant Harry , Payer Juraj

Introduction: Patients with acromegaly, despite normal or even high bone mineral density (BMD), have prevalent vertebral fractures (VFs). HR-pQCT studies in acromegaly have proposed that impaired trabecular bone microarchitecture possibly plays a role in fragility fracture development. As such, we hypothesized that trabecular bone score (TBS) would be low in patients with acromegaly.Aim of the study: To compare BMD and TBS in acromegaly patients with and...

ea0063p93 | Calcium and Bone 1 | ECE2019

Analysis of non-invasive DXA-derived bone structure parameters in patients with acromegaly with regards to vitamin D levels

Kužma Martin , Vaňuga Peter , Sagova Ivana , Pavai Dušan , Jackuliak Peter , Killinger Zdenko , Binkley Neil , Winzenrieth Renaud , Genant Harry , Payer Juraj

Introduction: Patients suffering from acromegaly, despite normal or even higher bone mineral density (BMD), have prevalent vertebral fractures (VFs). Impaired bone microarchitecture is involved fragility fracture development, but vitamin D status could be involved in this impairment.Aim of the study: Comparison of bone parameters such as BMD, trabecular bone score (TBS) and 3D-SHAPER parameters in acromegaly patients according to level of 25(OH)D3.<p...

ea0049gp38 | Bone & Calcium Homeostasis 1 | ECE2017

Decreased trabecular bone score but not bone mineral density in patients with acromegaly and concurrent hypogonadism: cross-sectional study with healthy controls

Kužma Martin , Pavai Dušan , Sagova Ivana , Killinger Zdenko , Jackuliak Peter , Vaňuga Anton , Vaňuga Peter , Payer Juraj

Introduction: Acromegaly is associated with higher prevalence of vertebral fractures (VFx) and bone microarchitecture potentially play a role in fracture development. Trabecular bone score (TBS), a novel indicator of bone microstructure could provide additional information.Objectives: Assessment of BMD, TBS and bone turnover markers (BTM) in acromegaly patients in comparison to healthy controls with regard to gender, hypogonadism and disease activity.</p...