Searchable abstracts of presentations at key conferences in endocrinology

ea0022oc1.1 | Diabetes and obesity | ECE2010

Role of newly identified immunosuppressive NK cells in autoimmunity

Ehlers Margret , Papewalis Claudia , Jacobs Benedikt , Thiel Annette , Schinner Sven , Willenberg Holger S , Scherbaum Werner A , Schott Matthias

Most recently, a completely new subset of NK cells with immunosuppressive functions has been identified. These cells are able to downregulate conventional NK cells in a PD1-ligand dependent manner and are, therefore, responsible for tumor outgrowth.The aim of our present study was to investigate the role of this new NK subset in autoimmunity. For this purpose, we used two independent mouse models. In the NOD mice, we found a large increase of suppressive...