Searchable abstracts of presentations at key conferences in endocrinology

ea0039oc7.4 | Oral Communications 7 | BSPED2015

The cost-effectiveness of the KIds in control of food structured education programme for adolescents with type 1 diabetes

Basirir Hasan , Brennan Alan , Jacques Richard , Pollard Daniel , Stevens Katherine , Freeman Jennifer , Wales Jeremy , Price Katherine

Objectives: Kids in control of food (KICK-OFF) is a 5-day structured education programme for 11–16 year olds with type 1 diabetes who use multiple daily insulin injections. This study evaluates whether KICk-OFF would be considered a cost effective use of NHS resources by decision makers in the UK.Methods: A cost effectiveness analysis comparing KICk-OFF to usual care was conducted. Data from the KICk-OFF trial were extrapolated to simulate lifetime ...

ea0039ep14 | Bone | BSPED2015

Increase in lean mass may augment gains in bone mass and size in patients with osteogenesis imperfecta treated with bisphosphonates

Gopal Kothandapani Jaya Sujatha , Sritharan Shironisha , Jacques Richard , Bishop Nick , Dimitri Paul

Background: The role of bisphosphonates in improving bone mass in patients with osteogenesis impefercta (OI) is well established. However, the impact of bisphosphonate therapy on body composition in relation to increasing bone mass remains relatively unexplored.Methods: Change in DXA-derived subtotal body (TBLH) and lumbar spine (LS: L1–L4) bone mineral content (BMC (g)), bone area (BA (cm2)), areal bone mineral density (aBMD (g/cm2<...

ea0058p007 | Bone | BSPED2018

Impact of type 1 diabetes mellitus on skeletal integrity and strength assessed by HRpQCT

Devaraja Janani , Dimitri Paul , Jacques Richard , Paggiosi Margaret , Clark Carolyn , Bishop Nick

Introduction: Adults with Type 1 Diabetes Mellitus (T1DM) are at risk of premature osteoporosis and fractures. The onset of T1DM typically starts during childhood and adolescence thus the effects of diabetes on the skeleton may be established in this period. Studies in children primarily use DXA to evaluate the effects of T1DM on bone with conflicting results. We present the first study in children assessing the impact of T1DM on skeletal microstructure and strength, using HRp...

ea0081p7 | Adrenal and Cardiovascular Endocrinology | ECE2022

Waking salivary cortisone as screening test for adrenal insufficiency

Debono Miguel , Elder Charlotte , Lewis Jen , Fearnside Jane , Caunt Sharon , Dixon Simon , Jacques Richard , Newell-Price John , Keevil Brian , Ross Richard

Introduction: In many endocrine centres the 250μg Short Synacthen (Cosyntropin) Test (SST) is the reference standard for the diagnosis of adrenal insufficiency (AI) 1, but it is time consuming, expensive, and requires hospital attendance and venepuncture. The morning physiological peak of cortisol shortly after waking is a good predictor for a negative SST; however, a morning serum cortisol requires venepuncture. Serum cortisol and salivary cortisone correlate ...

ea0086p299 | Adrenal and Cardiovascular | SFEBES2022

Screening for adrenal insufficiency using home waking salivary cortisone is accurate and lowers NHS costs

Debono Miguel , Elder Charlotte , Lewis Jen , Jacques Richard , Caunt Sharon , Fearnside Jane , Dixon Simon , Newell-Price John , Whitaker Martin , Keevil Brian , Ross Richard

Introduction: The 250µg Short Synacthen test (SST) is the reference standard for a diagnosis of adrenal insufficiency (AI) in most endocrine centres. The test is expensive and time consuming, requiring clinic attendance. We hypothesised that a cheaper home waking salivary cortisone (WSC) is predictive of the SST 30-minute cortisol >430 nmol/l cut-off and carried out a diagnostic accuracy study to assess the predictive value of the WSC in diagnosing and excluding AI. W...