Endocrine Abstracts

A young female with autosomal dominant hypoparathyroidism type 1 who had inherited the gene defect from her mother was under the care of paediatric endocrinologist. Since childhood she was on a large dose of calcium (elemental calcium 5 g) along with Vitamin D, potassium and magnesium replacements. Despite careful monitoring there was significant fluctuations in serum calcium levels which led to recurrent hospital admissions with hypercalcaemia and acute kidney injury or sever...

A 25-year-old woman with hypertension was referred with 12 months history of watery right eye and slowly growing swelling in the lateral wall of the right orbit. On examination there was proptosis with superior and medial displacement of the right globe. CT scan of facial bones revealed a 3.5 cm swelling with internal cortical scalloping and calcification arising from the zygoma within the right lateral orbital wall. Further lucent lesions were identified in the frontal bone, ...

A 63-year-old woman with a history of bipolar disorder and hypothyroidism under section 3 of the Mental Health Act in a psychiatric centre was admitted with severe hypothermia, bradycardia, hypotension and decreased GCS. She was on procyclidine and haloperidol for bipolar disorder and on intravenous antibiotics for 2 days for recurrent cellulitis in her leg. She was on levothyroxine 50 μg daily but was non compliant with her medications.Thyroid func...

Primary hyperparathyroidism (1 in 1000) (1) and occult vitamin D deficiency (14% of the healthy adult population) are relatively common disorders (2). Hypercalciuria, renal tract calcification and reduced bone mineral density (BMD) are recognised complications of primary hyperparathyroidism. We report details of the prevalence of vitamin D deficiency and complications in patients with primary hyperparathyroidism.It is a retrospective study of 44 patients...

A 63-year-old Caucasian female was admitted with a 12-month history of exertional breathlessness, anxiety attacks, syncopal episodes, diarrhoea, fatigue, reduced appetite, two stones weight loss, and dry facial and truncal flushing. Investigations revealed raised Urine 5-HIAA of 116 (RR <50 μmol/24 h) and raised Chromogranin A of 48 (RR <6 nmol/l). CT scan revealed an extensive soft tissue mass encasing the upper abdominal aorta, compressing the inferior vena cava...

A 34-year-old male with no significant past medical history presented with severe abdominal pain. On detailed questioning his symptoms included tremors, headache, sweating, and agitation. Despite recent weight gain he had obvious muscle wasting. On admission blood pressure was 166/107 mmHg. Abdominal examination revealed a palpable left upper quadrant mass.CT scan demonstrated a 15 cm mass in the left supernal region with extensive signs of haemorrhage i...