Searchable abstracts of presentations at key conferences in endocrinology

ea0021p215 | Endocrine tumours and neoplasia | SFEBES2009

Receptor-based scintigraphic imaging of insulinoma and glucagonoma in MEN-1

Sivappriyan Sivasubramaniam , Kurzawinski Tom , Bomanji Jamshed , Conway Gerard , Ahlquist James

Successful surgery for pancreatic neuro-endocrine tumours (NET) requires accurate tumour localisation. Interpretation of cross-sectional imaging is often difficult, particularly after pancreatic surgery. Imaging by somatostatin-receptor-scintigraphy with indium-labelled octreotide may be useful in identifying recurrent disease; however, octreotide scans may be negative in some pancreatic NET, due to a low level of expression of somatostatin receptors. The GLP-1 receptor is abu...

ea0103p50 | Miscellaneous/Other 1 | BSPED2024

Safety and efficacy of 18F-DOPA PET/CT scan under oral sedation in children with congenital hyperinsulinism

Gilbert Clare , Morgan Kate , Biassioni Lorenzo , Bomanji Jamshed , Dastamani Antonia

Background: Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycemia in infancy. The two main histological types, diffuse and focal, are clinically identical but differ in underlying genetic mechanisms, histopathology, and management. Fluorine-18 L-3,4-dihydroxyphenylalanine positron emission tomography/computed tomography (18F-DOPA PET/CT) can help differentiate focal from diffuse CHI and consequently aid in patient management. At our institution, ...

ea0050p266 | Neuroendocrinology and Pituitary | SFEBES2017

Patterns of recurrence, response to treatment and mortality in patients with malignant phaeochromocytomas and paragangliomas. – a single centre experience

Abdel-Aziz Tarek , Chung Teng-Teng , Bomanji Jamshed , Gaze Mark , Kurzawinski Tom

Introduction: Histology is a poor predictor of the malignant potential of phaeochromocytomas and paragangliomas (PPGL) and only the presence of distant metastasis confirms malignancy. This study reviews patterns of recurrence, treatment and mortality in patients with malignant PPGL presenting to our department at UCLH over 30 years.Materials and Methods: In our series of 128 patients with PPGL, 26 (20%) with maligna...

ea0050p266 | Neuroendocrinology and Pituitary | SFEBES2017

Patterns of recurrence, response to treatment and mortality in patients with malignant phaeochromocytomas and paragangliomas. – a single centre experience

Abdel-Aziz Tarek , Chung Teng-Teng , Bomanji Jamshed , Gaze Mark , Kurzawinski Tom

Introduction: Histology is a poor predictor of the malignant potential of phaeochromocytomas and paragangliomas (PPGL) and only the presence of distant metastasis confirms malignancy. This study reviews patterns of recurrence, treatment and mortality in patients with malignant PPGL presenting to our department at UCLH over 30 years.Materials and Methods: In our series of 128 patients with PPGL, 26 (20%) with maligna...

ea0050p016 | Adrenal and Steroids | SFEBES2017

The potential use of I-131 Norcholesterol scan for large adrenal mass

Alnaim Abdulrhman , Wan Ming Young Simon , Abdel-Aziz Tarek Ezzat , Chung Teng-Teng , Kurzawinski Tom , Bomanji Jamshed

Background: Characterisation of large adrenal lesion is challenging. There is no single robust imaging marker in defining benignity, especially for lesions which are greater than 4cm and are believed to carry increased risk of malignancy.A radiolabelled cholesterol analog tracer, I-131-Norcholesterol (NP-59), localises to adrenal cortical lesions. It has an established role in Conn’s syndrome. It is not expected to concent...

ea0050p016 | Adrenal and Steroids | SFEBES2017

The potential use of I-131 Norcholesterol scan for large adrenal mass

Alnaim Abdulrhman , Wan Ming Young Simon , Abdel-Aziz Tarek Ezzat , Chung Teng-Teng , Kurzawinski Tom , Bomanji Jamshed

Background: Characterisation of large adrenal lesion is challenging. There is no single robust imaging marker in defining benignity, especially for lesions which are greater than 4cm and are believed to carry increased risk of malignancy.A radiolabelled cholesterol analog tracer, I-131-Norcholesterol (NP-59), localises to adrenal cortical lesions. It has an established role in Conn’s syndrome. It is not expected to concent...

ea0033p20 | (1) | BSPED2013

18F-DOPA PET and enhanced CT imaging for congenital hyperinsulinism: Our experience of using oral sedation

Shah Pratik , Senniappan Senthil , du Preez Marguerite , Endozo Raymond , Townsend Caroline , Gilbert Clare , Morgan Kate , Hinchey Louise , Pierro Agostino , Biassoni Lorenzo , Olsen Oystein , Bomanji Jamshed , Hussain Khalid

Introduction: Congenital hyperinsulinism (CHI) is the most common cause of persistent hypoglycaemia in infants and children. Histologically there are two subgroups, diffuse and focal. Fluorine-18-L dihydroxyphenylalanine positron emission tomography (18F-DOPA PET/CT) helps to differentiate focal from diffuse CHI.Objective and hypotheses: To evaluate the feasibility of using 18F-DOPA PET/CT for the diagnosis of focal or diffuse CHI u...

ea0033p15 | (1) | BSPED2013

18F-DOPA PET MRI as a new imaging modality for the precise localisation of focal congenital hyperinsulinism

Senniappan Senthil , Shah Pratik , du Preez Marguerite , Endozo Raymond , O'Meara Celia , Townsend Caroline , Gilbert Clare , Morgan Kate , Hinchey Louise , Pierro Agostino , Biassoni Lorenzo , Olsen Oystein , Bomanji Jamshed , Hussain Khalid

Introduction: Congenital hyperinsulinism (CHI) includes two major histological subtypes; diffuse and focal. Fluorine-18-L dihydroxyphenylalanine positron emission tomography (18F-DOPA PET/CT) has been established as a novel imagining technique to differentiate focal from diffuse CHI. However CT provides only limited soft tissue contrast and exposes the patient to a significant radiation dose. PET/MRI could provide images with an excellent soft tissue contrast, very ...

ea0021p223 | Endocrine tumours and neoplasia | SFEBES2009

Open or laparoscopic surgery for phaeochromocytoma

Ezzat Tarek , Skipworth James , Raptis Dimitris , Conway Gerard , Baldweg Stefie , Bomanji Jamshed , Bouloux Pierre , Rolles Keith , Khoo Bernard , Hyatt Penny , Rossi Michaela , Barnard Maria , Anthony Karen , Stojanovic Nemanja , Cohen Mark , Katz Jonathan , Baynes Christopher , Russel Sabina , Ahlquist James , Kurzawinski Tom

Background: Surgical resection is the treatment of choice for phaeochromocytomas. Introduction of laparoscopic adrenalectomy (LA) led to a reduction in the number of open adrenalectomies (OA); however, there is limited information comparing the two techniques.Objectives: We report here a comparison of LA and OA operations for phaeochromocytoma performed over 20 years.Methods: We performed a retrospective review of all patients unde...