Endocrine Abstracts

Introduction: Generously supported by IPSEN)-->Acromegaly is associated with increased morbidity and mortality, mainly due to cardiovascular and metabolic complications and higher risk of malignancy. The treatment of choice is selective transsphenoidal surgery (TSS). Successful removal of somatotroph adenoma normalizes GH and IGF1 levels, which improves the patients prognosis. The efficacy of TSS depends on the tumor volume, parasell...

Introduction: Impaired glucose tolerance and overt diabetes mellitus are frequently associated with acromegaly. The aim of this study was to find whether these alterations could be reversed after transsphenoidal surgery.Patients and methods: Two hundred and thirty-nine acromegalic patients were studied before and 6–12 months after transsphenoidal surgery. Diagnosis of active acromegaly was established on the basis of widely recognized criteria. In e...