Searchable abstracts of presentations at key conferences in endocrinology

ea0016s22.3 | The good side of exercise | ECE2008

Why does physical exercise improve insulin sensitivity, the role of adipose tissue?

Polak Jan

Modern lifestyle diminished significantly the need of everyday exercise, which is probably one of the major factors leading to the development of several metabolic diseases including type 2 diabetes, hypertension and atherosclerosis with its deadly consequences. Epidemiological studies proved that higher levels of cardio-respiratory fitness are associated with lower mortality irrespective of fat stores. Physical activity reduces all-cause, cardiovascular as well as cancer asso...

ea0067o28 | Oral Presentations | EYES2019

Hypoxia modulates effects of fatty acids on human pancreatic β-cells

Šramek Jan , Němcova-Furstova Vlasta , Polak Jan , Kovar Jan

Objective: Saturated fatty acids (FAs), e.g. stearic acid (SA), induce apoptosis in pancreatic β-cells while unsaturated FAs, e.g. oleic acid (OA) have nearly no detrimental effect. Moreover, unsaturated FAs are capable of inhibiting the pro-apoptotic effect of saturated FAs. Hypoxia is also known to have deleterious effects on β-cell function and viability. In the present study, we have tested the modulatory effect of hypoxia on the effect of FAs on the growth and v...