Searchable abstracts of presentations at key conferences in endocrinology

ea0081p148 | Pituitary and Neuroendocrinology | ECE2022

AZP-3813, a bicyclic 16-amino acid peptide antagonist of the human growth hormone receptor as a potential new treatment for acromegaly

Milano Stephane , Kurasaki Haruaki , Tomiyama Tatsuya , Reid Patrick , Jan Van der Lely Aart , Culler Michael D.

Medical treatment of acromegaly is based on either suppressing pituitary GH secretion or inhibiting GH action by preventing interaction with its receptor in order to suppress the elevated levels of IGF1. AZP-3813 is a 16-amino acid, bicyclic peptide antagonist of the GH receptor (GHR) derived from peptide sequences discovered using a unique, cell-free in vitro transcription-translation system screened against the human GHR, and that was optimized by rational design to increase...

ea0070aep400 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Systematic screening reveals large number of undiagnosed and untreated cardiovascular risk factors in adults with prader-willi syndrome

Pellikaan Karlijn , Rosenberg Anna , Davidse Kirsten , Jan Van der Lely Aart , De Graaff Laura

Introduction: Prader-Willi syndrome (PWS) is a complex hypothalamic disorder, combining hypotonia, intellectual disability (ID), pituitary hormone deficiencies and hyperphagia. In PWS, up to 3% of patients die every year. In half of the patients, the cause of death is obesity related and / or of cardiovascular origin. Obesity is caused by hyperphagia combined with a low energy expenditure. Untreated hormone deficiencies like hypogonadism and hypothyroidism can cause low muscle...

ea0081p155 | Pituitary and Neuroendocrinology | ECE2022

Genetic subtype differences in relation to health problems among adults with Prader-Willi syndrome

Rosenberg Anna , Pellikaan Karlijn , Wellink Charlotte , Tellez Garcia Juan , van Abswoude Denise , van Zutven Laura , Bruggenwirth Hennie , Resnick James , Jan Van der Lely Aart , De Graaff Laura

Background: Prader-Willi syndrome (PWS) is a complex rare genetic disorder associated with hypothalamic dysfunction, pituitary hormone deficiencies, hyperphagia and (morbid) obesity. PWS is caused by loss of expression of paternally expressed genes on chromosome 15q11.2-q13. The most common genetic mechanisms leading to PWS are paternal deletion (DEL) and maternal uniparental disomy (mUPD). DELs can be subdivided in type 1 and (smaller) type 2 deletions (DEL-1, DEL-2). Most re...

ea0070aep748 | Pituitary and Neuroendocrinology | ECE2020

Soluble klotho: A possible predictor of quality of life in acromegaly patients

Coopmans Eva , El-Sayed Nour , Frystyk Jan , Erik Magnusson Nils , Otto Jorgensen Jens , Jan Van der Lely Aart , Janssen Joseph AM , Muhammad Ammar , Neggers Sebastian

Purpose: Although quality of life (QoL) is improved in patients with acromegaly after disease control, QoL correlates only weakly with traditional biomarkers. Our objective is to investigate a potential relation between the new serum biomarker soluble Klotho (sKlotho), GH and insulin-like growth factor 1 (IGF-1) levels and QoL.Methods: In this prospective cohort study, we investigated 54 acromegaly patients biochemically well-controlled on combination tr...

ea0014p79 | (1) | ECE2007

Unacylated ghrelin (UAG) enhances the early insulin response to meal, improves glucose metabolism and decreases free fatty acids levels in healthy volunteers

Prodam Flavia , Riganti Fabrizio , Gramaglia Elena , Benso Andrea , Lucatello Barbara , Broglio Fabio , Abribat Thierry , Jan van der Lely Aart , Ghigo Ezio

Ghrelin circulates in two different forms. Acylated ghrelin (AG), a natural ligand of the GH Secretagogue receptor (GHS-R) type 1a, exerts several biologic central and peripheral actions including stimulation of GH secretion, but also modulation of insulin secretion, glucose and lipid metabolism. Unacylated ghrelin (UAG), despite unable to bind the GHS-R1a, is biologically active showing some influence in vitro and in vivo on glucose and lipid metabolism likely m...

ea0014p561 | (1) | ECE2007

Effects of CST-8, a synthetic cortistatin analogue, in humans

Benso Andrea , Prodam Flavia , Gramaglia Elena , Riganti Fabrizio , Lucatello Barbara , Jan van der Lely Aart , Deghenghi Romano , Muccioli Giampiero , Ghigo Ezio , Broglio Fabio

Cortistatin (CST), a neuropeptide with high structural homology with somatostatin (SS), binds all SS receptor (SS-R) subtypes but, unlike SS, also shows high binding affinity to ghrelin (GRLN) receptor (GRLN-R). In humans CST exerts the same endocrine activities of SS, suggesting that the activation of the SS-R might mask the potential interaction with the GRLN system.CST-8, a synthetic CST-analogue devoid of any binding affinity to SS-R but capable to b...