Endocrine Abstracts

Background: Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor derived from the parafollicular C-cells of the thyroid gland. Mutations in the gene encoding the Rearranged during Transfection (RET) tyrosine kinase, play a vital role in the development of MTCs. In patients with distant metastases, only targeted therapy can prolong survival. Tyrosine kinase inhibitors (TKIs) block tyrosine kinases such as RET and thereby inhibit tumor proliferation. However, it is diffic...

Objectives: To analyze acute and late toxicities and long-term quality of life (QoL) in patients who underwent locoregional external beam radiotherapy (EBRT) for thyroid cancer and to assess the correlation of QoL with treatment characteristics.Methods: Patients treated with locoregional EBRT for thyroid cancer at University Medical Centre Groningen (UMCG) (2007-2023) were included. Patient/treatment characteristics were extracted from patient files retr...

Introduction: The worldwide incidence of thyroid cancer has shown a steady incline over the past 35 years. While differentiated thyroid cancers are mostly responsible for this increase, population-based studies also show elevated medullary thyroid cancer (MTC) incidence rates. MTC is a rare, C-cell derived thyroid cancer, with a variable disease course that challenges treatment and follow-up. To enable adequate care of this rare cancer, international guidelines and centralizat...