Searchable abstracts of presentations at key conferences in endocrinology

ea0026p165 | Neuroendocrinology | ECE2011

Role of IGF1 system in human longevity. A study in a wide population of centenarians and centenarians’ offspring

Vitale G , Brugts M P , Ogliari G , Castaldi D , Fatti L M , Hofland L J , Monti D , Cavagnini F , Franceschi C , Mari D , Janssen J A M J L

Increasing evidence has recently accumulated suggesting that IGF1 system is involved in the regulation of longevity. While in animal models alterations of IGF1 signalling increase life expectancy, in humans there are contradictory data. Centenarians are an extraordinary model to study human longevity, however, they present a number of drawbacks: rarity, frailty due to extreme age and lack of a control group of the same age. The availability of an age-matched control group is c...

ea0049gp116 | Endocrine Nursing | ECE2017

Recovery of the hypothalamus-pituitary-adrenal axis after transsphenoidal surgery for pituitary adenomas

van Eck J P , Neggers S J C M M , Janssen J A M J L , de Rijke Y B , Dallenga A H G , Nagtegaal A P , van der Lely A J , Feelders R A

Purpose: Hypopituitarism is frequently associated with lifelong replacement therapy. However, it has been suggested that recovery from hypopituitarism after transsphenoidal surgery (TSS) for pituitary adenomas may occur during follow up. The aim of this study was to assess the frequency of hypothalamus-pituitary-adrenal (HPA) axis recovery after TSS in patients with non-functioning pituitary adenomas and acromegaly.Methods: Over the 3-year observational ...

ea0026p363 | Adrenal medulla | ECE2011

Expression of IGF/mTOR pathway components in human pheochromocytomas and in vitro inhibition of PC12 rat pheochromocytoma cell growth by mTOR inhibitors

De Martino M C , Feelders R A , van Koetsveld P M , De Krijger R R , Janssen J A M J L , Sprij-Mooij D , Lamberts S W J , de Herder W W , Colao Annamaria , Pivonello Rosario , Hofland Leo

The pathogenesis of pheochromocytomas (pheo) is poorly understood and malignant pheo need new treatment options. mTOR inhibitors, as sirolimus (S) and everolimus (E), are new promising antineoplastic drugs.Aim: To evaluate whether the IGF/mTOR pathways have a role in the pathogenesis and whether S and E may have antiproliferative effects in pheo.In 24 human pheo and two normal adrenal medulla (NM), we evaluated the mRNA expression ...