Searchable abstracts of presentations at key conferences in endocrinology

ea0032p191 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2013

Pentraxin-3 as a more sensitive marker of coronary artery disease severity than C-reactive protein

Szkodzinski Janusz , Hudzik Bartosz , Danikiewicz Aleksander , Pietka-Rzycka Anna , Lekston Andrzej , Zubelewicz-Szkodzinska Barbara

Introduction: Pentraxin-3 (PTX3) is an acute-phase reactant that shares structural and functional homology with C-reactive protein (CRP). However, unlike CRP, which is synthesized mainly in the liver, PTX3 is produced at the site of inflammation. It has been suggested that PTX3 plays the same role in the periphery that CRP does in circulation. PTX3 may represent a rapid marker for local inflammation.Methods: Fifty three patients with stable coronary arte...

ea0014p17 | (1) | ECE2007

Does stress test influence Interleukin (IL)-2 and IL-8 concentration in serum patients with stable ischaemic heart disease?

Romanowski Wojciech , Szkodzinski Janusz , Kaszuba Andrzej , Blazelonis Adam , Muryn Zuzanna , Anna Pietka-Rzycka , Zubelewicz-Szkodzinska Barbara

Background: There is growing evidence that adhesion molecules, proinflammatory cells and cytokines play an important role in a variety of cardiac pathophysiological conditions; Cytokines are responsible for the modulation of immune and inflammatory processes. It has been suggested that cytokines such as IL-1, IL-2, IL-6, IL-10 and TNF alpha are important modulators of atherosclerotic effects with IL-2 and Interferon γ having a proinflammatory atherogenic effect and IL-8 a...

ea0014p18 | (1) | ECE2007

Concentration of inflammatory factors such as CRP (acute phase response protein) and Interleukin (IL)-6 in serum patients with stable ischemic heart disease during trimetazidine treatment

Szkodzinski Janusz , Szewczyk Marek , Romanowski Wojciech , Danikiewicz Aleksander , Muc-Wierzgon Malgorzata , Zubelewicz-Szkodzinska Barbara

Background: The patomechanism of developing ischemic heart disease (i.h.d.) is stenosis of coronary blood vessels with plaque placed on vascular endothelium built with monocytes/macrophages, foam cells, oxidized LDL, leukocytes, platelets and collagen. Atherosclerotic lesions are heavily infiltrated by cellular components associated with inflammation and influenced by other inflammatory factors. Trimetazidine, a clinically effective antianginal agent acts by optimizing cardiac...